Abstract：
Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.
摘要：
细胞连接,包括锚定,闭塞和连通连接处，在多细胞组织的结构和功能组织中起着不可或缺的作用，包括肝脏。具体来说,肝细胞连接介导肝细胞之间的细胞间粘附和通讯。肝细胞连接网络的建立是正常肝功能的先决条件。肝细胞连接确实支持肝脏特异性特征并控制肝脏生命周期的基本方面。本文综述了细胞连接及其组成部分在肝脏生理学中的作用。从而也讨论了他们参与肝功能障碍，包括肝脏疾病和毒性。
