PDF(Pubmed)
Abstract：
UNASSIGNED: In patients receiving anti-TNF-α drugs for ankylosing spondylitis, monitoring purpuric and ischemic skin lesions is crucial. This case underscores the significance of identifying and addressing drug-induced vasculitis while stressing the necessity for prompt evaluation and exploration of alternative treatment options to safeguard patient well-being.
UNASSIGNED: The case discusses a 38-year-old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate-sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug-related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.
UNASSIGNED: The case discusses a 38-year-old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate-sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug-related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.
摘要：
■在接受抗TNF-α药物治疗强直性脊柱炎的患者中，监测紫癜性和缺血性皮肤病变至关重要。此病例强调了识别和解决药物引起的血管炎的重要性，同时强调了迅速评估和探索替代治疗方案以保障患者健康的必要性。
该病例讨论了一名38岁女性，有强直性脊柱炎（AS）病史，并伴有皮肤病变，包括紫癜性皮肤损伤和右脚手指缺血,在开始使用阿达木单抗治疗后。排除其他潜在原因后，如感染和恶性肿瘤，该患者接受了与使用阿达木单抗相关的中度血管血管炎的诊断.停用阿达木单抗和高剂量糖皮质激素和环磷酰胺静脉脉冲治疗导致她的缺血性病变消退。该病例强调了在新的皮肤病变患者中考虑药物相关副作用的重要性，特别是在风湿性疾病如AS的背景下。
该病例讨论了一名38岁女性，有强直性脊柱炎（AS）病史，并伴有皮肤病变，包括紫癜性皮肤损伤和右脚手指缺血,在开始使用阿达木单抗治疗后。排除其他潜在原因后，如感染和恶性肿瘤，该患者接受了与使用阿达木单抗相关的中度血管血管炎的诊断.停用阿达木单抗和高剂量糖皮质激素和环磷酰胺静脉脉冲治疗导致她的缺血性病变消退。该病例强调了在新的皮肤病变患者中考虑药物相关副作用的重要性，特别是在风湿性疾病如AS的背景下。
