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Abstract：
The transition of fibroblasts to myofibroblasts (FMT) represents a pivotal process in wound healing, tissue repair, and fibrotic diseases. This intricate transformation involves dynamic changes in cellular morphology, gene expression, and extracellular matrix remodeling. While extensively studied at the molecular level, recent research has illuminated the regulatory roles of non-coding RNAs (ncRNAs) in orchestrating FMT. This review explores the emerging roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating this intricate process. NcRNAs interface with key signaling pathways, transcription factors, and epigenetic mechanisms to fine-tune gene expression during FMT. Their functions are critical in maintaining tissue homeostasis, and disruptions in these regulatory networks have been linked to pathological fibrosis across various tissues. Understanding the dynamic roles of ncRNAs in FMT bears therapeutic promise. Targeting specific ncRNAs holds potential to mitigate exaggerated myofibroblast activation and tissue fibrosis. However, challenges in delivery and specificity of ncRNA-based therapies remain. In summary, ncRNAs emerge as integral regulators in the symphony of FMT, orchestrating the balance between quiescent fibroblasts and activated myofibroblasts. As research advances, these ncRNAs appear to be prospects for innovative therapeutic strategies, offering hope in taming the complexities of fibrosis and restoring tissue equilibrium.
摘要：
成纤维细胞向肌成纤维细胞（FMT）的转变代表了伤口愈合的关键过程，组织修复,和纤维化疾病。这种复杂的转变涉及细胞形态的动态变化，基因表达，和细胞外基质重塑。虽然在分子水平上进行了广泛的研究，最近的研究揭示了非编码RNA（ncRNA）在协调FMT中的调节作用。这篇综述探讨了ncRNAs的新兴作用，包括microRNAs（miRNAs），长链非编码RNA（lncRNA），和环状RNAs(circRNAs)，在调节这个复杂的过程中。NcRNAs与关键信号通路连接，转录因子，以及在FMT过程中微调基因表达的表观遗传机制。它们的功能在维持组织稳态方面至关重要，这些调节网络的破坏与各种组织的病理性纤维化有关。了解ncRNAs在FMT中的动态作用具有治疗前景。靶向特异性ncRNAs具有减轻过度肌成纤维细胞活化和组织纤维化的潜力。然而,基于ncRNA的疗法在递送和特异性方面的挑战仍然存在。总之,ncRNAs在FMT交响乐中作为整体调节因子出现，协调静止的成纤维细胞和激活的肌成纤维细胞之间的平衡。随着研究的进展,这些ncRNAs似乎是创新治疗策略的前景，为驯服纤维化的复杂性和恢复组织平衡提供了希望。
