PM2.5 暴露通过下调 P2Y2 受体 / CFTR 途径抑制跨上皮阴离子短路电流。
关键词: P2Y2 receptor asthma cystic fibrosis transmembrane regulator fine particulate matter short-circuit current
Mesh : Animals Mice Receptors, Purinergic P2Y2 / metabolism genetics Asthma / metabolism pathology drug therapy chemically induced immunology Particulate Matter / adverse effects toxicity Cystic Fibrosis Transmembrane Conductance Regulator / metabolism genetics Humans Adenosine Triphosphate / metabolism Ovalbumin / immunology Signal Transduction / drug effects Epithelial Cells / drug effects metabolism Down-Regulation / drug effects Respiratory Mucosa / metabolism drug effects pathology Bronchoalveolar Lavage Fluid / cytology chemistry immunology
来 源:
DOI:10.7150/ijms.96777
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