PDF(Pubmed)
Abstract：
The utilization of extracellular vesicles (EVs) in wound healing has been well-documented. However, the direct administration of free EVs via subcutaneous injection at wound sites may result in the rapid dissipation of bioactive components and diminished therapeutic efficacy. Functionalized hydrogels provide effective protection, as well as ensure the sustained release and bioactivity of EVs during the wound healing process, making them an ideal candidate material for delivering EVs. In this review, we introduce the mechanisms by which EVs accelerate wound healing, and then elaborate on the construction strategies for engineered EVs. Subsequently, we discuss the synthesis strategies and application of hydrogels as delivery systems for the sustained release of EVs to enhance complicated wound healing. Furthermore, in the face of complicated wounds, functionalized hydrogels with specific wound microenvironment regulation capabilities, such as antimicrobial, anti-inflammatory, and immune regulation, used for loading engineered EVs, provide potential approaches to addressing these healing challenges. Ultimately, we deliberate on potential future trajectories and outlooks, offering a fresh viewpoint on the advancement of artificial intelligence (AI)-energized materials and 3D bio-printed multifunctional hydrogel-based engineered EVs delivery dressings for biomedical applications.
摘要：
细胞外囊泡(EV)在伤口愈合中的利用已得到充分证明。然而,通过在伤口部位皮下注射直接施用游离EV可能导致生物活性成分的快速消散和治疗功效降低.功能化水凝胶提供有效的保护，以及确保伤口愈合过程中电动汽车的持续释放和生物活性，使它们成为交付电动汽车的理想候选材料。在这次审查中,我们介绍了电动汽车加速伤口愈合的机制，然后详细阐述工程电动汽车的建设策略。随后，我们讨论了水凝胶作为缓释系统的合成策略和应用，以促进复杂的伤口愈合。此外，面对复杂的伤口,具有特定伤口微环境调节能力的功能化水凝胶，如抗菌剂，抗炎,和免疫调节，用于加载工程电动汽车，提供解决这些治疗挑战的潜在方法。最终,我们仔细研究潜在的未来轨迹和前景，为生物医学应用的人工智能（AI）赋能材料和3D生物打印多功能基于水凝胶的工程电动汽车输送敷料的发展提供了新的观点。
