UNASSIGNED: A retrospective single centre cohort study was conducted. Pediatric PHTS patients who received thyroid ultrasound surveillance before age 18 between 2016-2023 were included. Patients\' medical records have been reviewed. Primary outcomes included prevalence and time to develop thyroid nodules ≥10mm, nodular growth, goiter, thyroiditis and DTC. Descriptive statistics and Kaplan-Meier analyses were performed.
UNASSIGNED: Forty-three patients were included. Two patients (5%) were diagnosed with DTC at ages 12 and 17. Both DTCs were identified as minimally invasive follicular carcinoma at stages pT3NxMx and pT1NxMx respectively. A total of 84% were diagnosed with thyroid abnormalities at a median age of 12 years (range 9-18). Most common findings were benign, including nodular disease (74%), goiter (30%) and autoimmune thyroiditis (12%). Nodular growth was observed in 14 patients (33%) resulting in (hemi)thyroidectomy in 7 patients (16%).
UNASSIGNED: Thyroid ultrasound surveillance resulted in the detection of DTC in 2/43 PHTS patients before age 18. These findings support the recommendation to initiate thyroid ultrasound surveillance in children at least from age 12, preferably within an expertise centre.
■进行回顾性单中心队列研究。包括在2016-2023年之间在18岁之前接受甲状腺超声监测的小儿PHTS患者。已审查患者的医疗记录。主要结果包括患病率和发生甲状腺结节≥10mm的时间。结节状生长,甲状腺肿,甲状腺炎和DTC。进行描述性统计和Kaplan-Meier分析。
■纳入43例患者。两名患者(5%)在12岁和17岁时被诊断为DTC。两种DTC分别在pT3NxMx和pT1NxMx阶段被鉴定为微创滤泡癌。在中位年龄为12岁(范围9-18)时,共有84%的人被诊断出患有甲状腺异常。最常见的发现是良性的,包括结节性疾病(74%),甲状腺肿(30%)和自身免疫性甲状腺炎(12%)。在14例患者(33%)中观察到结节生长,导致7例患者(16%)进行(半)甲状腺切除术。
■甲状腺超声监测导致在18岁之前的2/43PHTS患者中检测到DTC。这些发现支持建议至少从12岁开始对儿童进行甲状腺超声监测,最好在专家中心内进行。