PDF(Pubmed)
Abstract：
BACKGROUND: Chronic nonspecific cheilitis is a complex condition characterized by persistent lip peeling and discomfort. This case report explores the clinical progression of a patient with history of tongue squamous cell carcinoma and subsequent Tislelizumab treatment, presenting with persistent lip peeling.
METHODS: A patient with a history of tongue squamous cell carcinoma (T2N0M0), treated with chemotherapy, surgery, and Tislelizumab, presented with six months of persistent lip peeling. Clinical examination revealed distinct features of chronic nonspecific cheilitis with infectious angular cheilitis (Oral Candidiasis). A tailored treatment plan, emphasizing oral hygiene practices and local treatments with Sodium Bicarbonate, Tacrolimus ointment, and Chlortetracycline ointment. Follow-up visits demonstrated sustained improvement, highlighting the significance of individualized approaches.
CONCLUSIONS: This case underscores the importance of recognizing and managing oral manifestations in patients with a history of cancer and immunotherapy. The patient\'s response to treatment suggests that a multifaceted approach, combining local therapy with lifestyle modifications, can be effective in managing chronic nonspecific cheilitis associated with immunotherapy. Routine follow-up appointments, guided by personalized medicine principles, contribute to sustained patient well-being.
METHODS: A patient with a history of tongue squamous cell carcinoma (T2N0M0), treated with chemotherapy, surgery, and Tislelizumab, presented with six months of persistent lip peeling. Clinical examination revealed distinct features of chronic nonspecific cheilitis with infectious angular cheilitis (Oral Candidiasis). A tailored treatment plan, emphasizing oral hygiene practices and local treatments with Sodium Bicarbonate, Tacrolimus ointment, and Chlortetracycline ointment. Follow-up visits demonstrated sustained improvement, highlighting the significance of individualized approaches.
CONCLUSIONS: This case underscores the importance of recognizing and managing oral manifestations in patients with a history of cancer and immunotherapy. The patient\'s response to treatment suggests that a multifaceted approach, combining local therapy with lifestyle modifications, can be effective in managing chronic nonspecific cheilitis associated with immunotherapy. Routine follow-up appointments, guided by personalized medicine principles, contribute to sustained patient well-being.
摘要：
背景：慢性非特异性唇炎是一种复杂的疾病，其特征是持续的嘴唇脱皮和不适。该病例报告探讨了患有舌鳞状细胞癌病史并随后进行Tislelizumab治疗的患者的临床进展。表现为持久的嘴唇脱皮。
方法：患者有舌鳞状细胞癌（T2N0M0）病史，用化疗治疗，手术,和Tislelizumab,出现六个月的持续唇脱皮。临床检查显示慢性非特异性唇炎伴感染性角性唇炎（口腔念珠菌病）的明显特征。量身定制的治疗计划，强调口腔卫生习惯和局部治疗碳酸氢钠，他克莫司软膏,和金霉素软膏.后续访问显示持续改善，强调个性化方法的重要性。
结论：该病例强调了识别和管理有癌症和免疫治疗史的患者口腔表现的重要性。患者对治疗的反应表明，采用多方面的方法，将局部治疗与生活方式的改变相结合，可以有效治疗与免疫治疗相关的慢性非特异性唇炎。例行随访预约,以个性化医疗原则为指导，有助于持续的患者福祉。
方法：患者有舌鳞状细胞癌（T2N0M0）病史，用化疗治疗，手术,和Tislelizumab,出现六个月的持续唇脱皮。临床检查显示慢性非特异性唇炎伴感染性角性唇炎（口腔念珠菌病）的明显特征。量身定制的治疗计划，强调口腔卫生习惯和局部治疗碳酸氢钠，他克莫司软膏,和金霉素软膏.后续访问显示持续改善，强调个性化方法的重要性。
结论：该病例强调了识别和管理有癌症和免疫治疗史的患者口腔表现的重要性。患者对治疗的反应表明，采用多方面的方法，将局部治疗与生活方式的改变相结合，可以有效治疗与免疫治疗相关的慢性非特异性唇炎。例行随访预约,以个性化医疗原则为指导，有助于持续的患者福祉。
