PDF(Pubmed)
Abstract：
CONCLUSIONS: Immune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell maturation, were associated with a decreased risk of CLL, even >10 years after blood draw. Our findings suggest that BAFF could be a useful biomarker to assess risk among individuals at high risk, such as those with monoclonal b-cell lymphocytosis.
摘要：
结论：免疫失调被认为是导致慢性淋巴细胞白血病（CLL）风险的原因，但生物学机制尚不清楚。我们发现B细胞活化因子（BAFF）的血清水平升高，B细胞成熟的重要调节因子,与CLL风险降低有关，甚至>10年后抽血。我们的研究结果表明，BAFF可能是评估高风险个体风险的有用生物标志物。例如单克隆b细胞淋巴细胞增多症。
