%0 Journal Article
%T Serum levels of B-cell activating factor are associated with a reduced risk of chronic lymphocytic leukemia.
%A Frost E
%A Hofmann JN
%A Huang WY
%A Frazer-Abel AA
%A Deane KD
%A Berndt SI
%J Blood Cancer J
%V 14
%N 1
%D 2024 Aug 7
%M 39112445
%F 9.812
%R 10.1038/s41408-024-01106-7
%X <B>CONCLUSIONS: </B>Immune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell maturation, were associated with a decreased risk of CLL, even >10 years after blood draw. Our findings suggest that BAFF could be a useful biomarker to assess risk among individuals at high risk, such as those with monoclonal b-cell lymphocytosis.