关键词: Default Failure NTEP Relapse Treatment outcomes Tuberculosis

Mesh : Humans Male Female Adult Antitubercular Agents / therapeutic use Longitudinal Studies Treatment Outcome Middle Aged Young Adult India / epidemiology Tuberculosis, Pulmonary / drug therapy diagnosis epidemiology Adolescent Tuberculosis / diagnosis drug therapy epidemiology Cough / etiology Age Factors Logistic Models Social Support

来  源:   DOI:10.1016/j.ijtb.2023.06.007

Abstract:
BACKGROUND: Tuberculosis disease epidemiology is closely related to social and economic conditions which make its prevention, control and cure challenging. Early diagnosis and adequate treatment will help to prevent various tuberculosis related morbidities. Factors such as adverse effects of drugs, transportation cost, family support, distance to the treatment center, personal habits, co morbid conditions, and patients\' multiple obligations concerning to their employment, family and society have an impact on the treatment outcomes.
OBJECTIVE: To know the factors affecting tuberculosis treatment outcome among newly diagnosed tuberculosis patients.
METHODS: A total of 261 Tuberculosis patients registered in NTEP under District tuberculosis centre were enrolled using universal sampling method. First follow up was done at the end of intensive phase i.e. End of 2 months. Second follow up was done after completion of treatment i.e., End of 6th month.
RESULTS: Majority 59% participants were diagnosed as smear negative at 2nd month follow up and 45.21% and 28.73% participants were diagnosed as cured and treatment completed respectively at 6th month follow up. 73.95% participants had successful outcome. Multivariate logistic regression analysis showed that treatment outcomes of tuberculosis were affected by type of house (pucca house), presence of cough, past history of tuberculosis, family support, supervision by family and support of supervisor.
CONCLUSIONS: Overall treatment success rate was 73.95%. The contributing factors for successful outcome of tuberculosis were age, past history of TB, type of house, presence of cough and fever, weight gain, family support, supervision by family and support of supervisor.
摘要:
背景:结核病流行病学与社会经济条件密切相关,控制和治疗具有挑战性。早期诊断和适当的治疗将有助于预防各种结核病相关的发病率。药物不良反应等因素,运输成本,家庭支持,距离治疗中心,个人习惯,同病态条件,和患者对其就业的多重义务,家庭和社会对治疗结果有影响。
目的:了解初诊肺结核患者中影响肺结核治疗转归的因素。
方法:采用普选抽样方法,纳入地区结核病中心NTEP登记的261例结核病患者。第一次随访在密集阶段结束时进行,即2个月结束。第二次随访是在治疗完成后进行的,即6月底
结果:大多数59%的参与者在第2个月随访时被诊断为涂片阴性,45.21%和28.73%的参与者在第6个月随访时分别被诊断为治愈和治疗完成。73.95%的参与者有成功的结果。多因素logistic回归分析显示,结核病的治疗结果受房屋类型(puccahouse)的影响,咳嗽的存在,既往有结核病史,家庭支持,家人的监督和主管的支持。
结论:总体治疗成功率为73.95%。结核病成功结局的因素是年龄,结核病过去的历史,房子的类型,咳嗽和发烧,体重增加,家庭支持,家人的监督和主管的支持。
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