Abstract：
UNASSIGNED: To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).
UNASSIGNED: In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in temperature. In a series of in silico studies, we compared the acoustic focal profiles produced by a ring array US transducer transmitting at different frequencies and further investigated the effectiveness of UST-guidance in implementing aberration correction to enhance the focal profile. In vitro experiments evaluated the capability of using a ring array US transducer to generate and maintain MHTh and the accuracy of using UST to monitor temperature changes.
UNASSIGNED: The simulations demonstrated that a ring array US transducer achieves symmetrical and localized acoustic focusing. In a heterogenous tissue model, a ring array US transducer achieved a superior acoustic focus by implementing aberration correction with guidance from UST. In vitro experiments demonstrated the capability of a ring array US transducer to generate MHTh in a tissue-mimicking phantom in an average of 117 ± 18 s and subsequently maintain MHTh. Lastly, a ring array US transducer utilized UST to track temperature changes in a preheated water-filled inclusion while it passively cooled from 45 °C to 25 °C, with a maximum error of 0.58 °C.
UNASSIGNED: A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. Utilizing UST thermometry with the same ring array US transducer will allow for implementing an image-guided, temperature-controlled, all-acoustic MHTh system.
UNASSIGNED: In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in temperature. In a series of in silico studies, we compared the acoustic focal profiles produced by a ring array US transducer transmitting at different frequencies and further investigated the effectiveness of UST-guidance in implementing aberration correction to enhance the focal profile. In vitro experiments evaluated the capability of using a ring array US transducer to generate and maintain MHTh and the accuracy of using UST to monitor temperature changes.
UNASSIGNED: The simulations demonstrated that a ring array US transducer achieves symmetrical and localized acoustic focusing. In a heterogenous tissue model, a ring array US transducer achieved a superior acoustic focus by implementing aberration correction with guidance from UST. In vitro experiments demonstrated the capability of a ring array US transducer to generate MHTh in a tissue-mimicking phantom in an average of 117 ± 18 s and subsequently maintain MHTh. Lastly, a ring array US transducer utilized UST to track temperature changes in a preheated water-filled inclusion while it passively cooled from 45 °C to 25 °C, with a maximum error of 0.58 °C.
UNASSIGNED: A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. Utilizing UST thermometry with the same ring array US transducer will allow for implementing an image-guided, temperature-controlled, all-acoustic MHTh system.
摘要：
■为了证明使用环形阵列超声（US）换能器的可行性，由超声断层成像（UST）引导，用于产生和监测轻度高热（MHTH）。
■设计了计算机模拟和体外实验，以评估环形阵列US换能器产生MHTh和监测温度变化的功效。在一系列的计算机模拟研究中，我们比较了环形阵列US换能器在不同频率下发射所产生的声学焦点轮廓，并进一步研究了UST引导在实施像差校正以增强焦点轮廓方面的有效性。体外实验评估了使用环形阵列US换能器产生和维持MHTh的能力以及使用UST监测温度变化的准确性。
■模拟表明，环形阵列US换能器实现了对称和局部声学聚焦。在异质组织模型中，环形阵列US换能器通过在UST的指导下实施像差校正，实现了出色的声学聚焦。体外实验证明了环形阵列US换能器在平均117±18s的组织模拟体模中产生MHTh并随后维持MHTh的能力。最后,AringarrayUStransducerusedUSTtotracktemperaturechangesinapreferredwater-filledinclusionwhileitpassivelycooledfrom45°Cto25°C,最大误差为0.58°C。
■环形阵列US换能器可以无创地产生和监测MHTh，克服了当前临床系统的许多局限性。换能器的闭合几何形状对于声聚焦和UST引导是最佳的，可以改善异质介质中的像差校正。利用UST测温与相同的环形阵列US换能器将允许实现图像引导，温度控制,全声MHTH系统。
■设计了计算机模拟和体外实验，以评估环形阵列US换能器产生MHTh和监测温度变化的功效。在一系列的计算机模拟研究中，我们比较了环形阵列US换能器在不同频率下发射所产生的声学焦点轮廓，并进一步研究了UST引导在实施像差校正以增强焦点轮廓方面的有效性。体外实验评估了使用环形阵列US换能器产生和维持MHTh的能力以及使用UST监测温度变化的准确性。
■模拟表明，环形阵列US换能器实现了对称和局部声学聚焦。在异质组织模型中，环形阵列US换能器通过在UST的指导下实施像差校正，实现了出色的声学聚焦。体外实验证明了环形阵列US换能器在平均117±18s的组织模拟体模中产生MHTh并随后维持MHTh的能力。最后,AringarrayUStransducerusedUSTtotracktemperaturechangesinapreferredwater-filledinclusionwhileitpassivelycooledfrom45°Cto25°C,最大误差为0.58°C。
■环形阵列US换能器可以无创地产生和监测MHTh，克服了当前临床系统的许多局限性。换能器的闭合几何形状对于声聚焦和UST引导是最佳的，可以改善异质介质中的像差校正。利用UST测温与相同的环形阵列US换能器将允许实现图像引导，温度控制,全声MHTH系统。
