Abstract：
Carrier-free nanodrugs are a novel type of drug constructed by the self-assembly of drug molecules without carrier involvement. They have the characteristics of small particle size, easy penetration of various barriers, targeting tumors, and efficient release. In recent years, carrier-free nanodrugs have become a hot topic in tumor therapy as they solve the problems of low drug loading, poor biocompatibility, and low uptake efficiency of carrier nanodrugs. A series of recent studies have shown that carrier-free nanodrugs play a vital role in the treatment of various tumors, with similar or better effects than carrier nanodrugs. Based on the literature published in the past decades, this paper first summarizes the recent progress in the assembly modes of carrier-free nanodrugs, then describes common therapeutic modalities of carrier-free nanodrugs in tumor therapy, and finally depicts the existing challenges along with future trends of carrier-free nanodrugs. We hope that this review can guide the design and application of carrier-free nanodrugs in the future.
摘要：
无载体纳米药物是由药物分子在没有载体参与的情况下自组装而构建的新型药物。它们具有粒径小的特点，容易穿透各种屏障，靶向肿瘤，高效释放。近年来,无载体纳米药物解决了低载药量的问题,成为肿瘤治疗的热点,生物相容性差，和低吸收效率的载体纳米药物。最近的一系列研究表明,无载体纳米药物在各种肿瘤的治疗中起着至关重要的作用,与载体纳米药物相似或更好的效果。根据过去几十年发表的文献，本文首先综述了无载体纳米药物组装方式的最新进展,然后描述了无载体纳米药物在肿瘤治疗中的常见治疗方式，最后描述了现有的挑战以及无载体纳米药物的未来趋势。我们希望本综述能够指导未来无载体纳米药物的设计和应用。
