Abstract：
Health-related quality of life (HRQoL) measures individual well-being across physical, psychological, and social domains. Patients with predominantly antibody deficiency (PAD) are at risk for morbidity and mortality, however, the effect of these complications on HRQoL requires additional study. Patients with PAD were asked to voluntarily complete the Centers for Disease Control (CDC) HRQoL-14 Healthy Days Measure questionnaire. These results were compared to data from the CDC-initiated Behavioral Risk Factor Surveillance System (BRFSS), a cross-sectional questionnaire including questions from CDC-HRQOL-14. Statistical analyses included two-proportion Z-test, t-tests, and analysis of variance. 83 patients with PAD completed the survey. Patients were sub-stratified into mild (23.7%), moderate (35.5%), severe (40.8%), and secondary (8.4%) PAD. \"Fair or poor\" health status was reported in 52.6% of PAD patients. Mental health challenges ≥ 14 days/month occurred in 25% of patients. Physical health issues ≥ 14 days/month was reported in 44.7% of patients. Activity limitations were noted by 80.3% of patients. There were no statistically significant differences by PAD severity. Patients with autoimmune and inflammatory disease co-morbidities reported more mental health challenges compared to those without (78% vs. 54.3%, p = 0.02). Compared to the CDC-BRFSS data, significantly more patients with PAD reported \"fair or poor\" health status (53% vs 12.0%; p < 0.0001), mental health challenges (24.1% vs 14.7%; p = 0.02), and poor physical health (44.6% vs 8.0%; p < 0.0001). Patients with PAD had significantly reduced HRQoL compared to CDC-BRFSS respondents from a similar geographical region. Decreased HRQoL was prevalent across all PAD severity levels. Additional research is needed to improve HRQoL for patients with PAD.
摘要：
健康相关生活质量(HRQoL)衡量个人健康状况，心理,和社会领域。主要为抗体缺乏（PAD）的患者有发病和死亡的风险。然而,这些并发症对HRQoL的影响需要进一步研究.PAD患者被要求自愿完成疾病控制中心（CDC）HRQoL-14健康日测量问卷。将这些结果与CDC发起的行为危险因素监测系统（BRFSS）的数据进行比较，包括CDC-HRQOL-14问题的横断面问卷。统计分析包括两比例Z检验，t检验,和方差分析。83例PAD患者完成了调查。患者分为轻度（23.7％），中等(35.5%)，严重（40.8%），和二级（8.4%）PAD。据报道，52.6%的PAD患者的健康状况“正常或不良”。25％的患者出现≥14天/月的心理健康挑战。44.7%的患者报告身体健康问题≥14天/月。80.3%的患者注意到活动限制。PAD严重程度差异无统计学意义。与没有自身免疫性和炎症性疾病合并症的患者相比，有更多的心理健康挑战（78％vs.54.3%,p=0.02)。与CDC-BRFSS数据相比，显着更多的PAD患者报告“正常或不良”健康状况（53％vs12.0％；p<0.0001），心理健康挑战（24.1%vs14.7%；p=0.02），身体健康状况差（44.6%vs8.0%；p<0.0001）。与来自相似地理区域的CDC-BRFSS受访者相比，PAD患者的HRQoL显着降低。所有PAD严重程度均普遍降低HRQoL。需要更多的研究来改善PAD患者的HRQoL。
