Abstract：
UNASSIGNED: This study aimed to investigate the association between sex hormones and the risk of pulmonary fibrosis by conducting a meta-analysis of previously published studies.
UNASSIGNED: We executed a comprehensive search of the PubMed, Embase, Cochrane Library, and Web of Science databases to locate pertinent studies published up to April 2024. We included studies that reported the association between sex hormones and the risk of pulmonary fibrosis. Standardized mean difference (SMD) with 95% confidence intervals (CIs) were calculated using a random-effects model.
UNASSIGNED: A total of 10 articles, encompassing 1371 patients, were finally incorporated in this meta-analysis. Based on the evaluation of the included studies, it was observed that the levels of dehydroepiandrosterone sulfate (DHEA-S) (pooled SMD: -0.72, 95% CI: -1.21 to -0.24, p < 0.001), testosterone (pooled SMD: -1.25, CI: -2.39 and -0.11, p < 0.001) and estrogen (pooled SMD: -0.56, 95% CI: -0.96 to -0.15, p < 0.001) were significantly lower in patients with pulmonary fibrosis, whereas the levels of luteinizing hormone (LH) remained unaffected. Publication bias was ruled out through funnel plots.
UNASSIGNED: This meta-analysis indicates that reduced levels of DHEA-S, testosterone, estrogen may serve as potential risk factors for pulmonary fibrosis. There is a pressing need for additional studies to confirm this association and explore the underlying biological mechanisms. Clinicians should recognize the potential influence of sex hormones in the etiology of pulmonary fibrosis and consider this aspect during the patient management process.
UNASSIGNED: We executed a comprehensive search of the PubMed, Embase, Cochrane Library, and Web of Science databases to locate pertinent studies published up to April 2024. We included studies that reported the association between sex hormones and the risk of pulmonary fibrosis. Standardized mean difference (SMD) with 95% confidence intervals (CIs) were calculated using a random-effects model.
UNASSIGNED: A total of 10 articles, encompassing 1371 patients, were finally incorporated in this meta-analysis. Based on the evaluation of the included studies, it was observed that the levels of dehydroepiandrosterone sulfate (DHEA-S) (pooled SMD: -0.72, 95% CI: -1.21 to -0.24, p < 0.001), testosterone (pooled SMD: -1.25, CI: -2.39 and -0.11, p < 0.001) and estrogen (pooled SMD: -0.56, 95% CI: -0.96 to -0.15, p < 0.001) were significantly lower in patients with pulmonary fibrosis, whereas the levels of luteinizing hormone (LH) remained unaffected. Publication bias was ruled out through funnel plots.
UNASSIGNED: This meta-analysis indicates that reduced levels of DHEA-S, testosterone, estrogen may serve as potential risk factors for pulmonary fibrosis. There is a pressing need for additional studies to confirm this association and explore the underlying biological mechanisms. Clinicians should recognize the potential influence of sex hormones in the etiology of pulmonary fibrosis and consider this aspect during the patient management process.
摘要：
■本研究旨在通过对先前发表的研究进行荟萃分析，探讨性激素与肺纤维化风险之间的关系。
■我们对PubMed进行了全面搜索，Embase,科克伦图书馆,和WebofScience数据库，以查找截至2024年4月发表的相关研究。我们纳入了报道性激素与肺纤维化风险之间关联的研究。使用随机效应模型计算具有95％置信区间（CI）的标准化平均差（SMD）。
■共十篇，涵盖1371名患者，最终纳入本荟萃分析。根据对纳入研究的评估，观察到硫酸脱氢表雄酮（DHEA-S）的水平（合并SMD：-0.72，95％CI：-1.21至-0.24，p<0.001），肺纤维化患者的睾酮（合并SMD：-1.25，CI：-2.39和-0.11，p<0.001）和雌激素（合并SMD：-0.56，95％CI：-0.96至-0.15，p<0.001）显着降低，而黄体生成素（LH）水平未受影响。通过漏斗图排除了出版偏倚。
■这项荟萃分析表明DHEA-S水平降低，睾丸激素，雌激素可能是肺纤维化的潜在危险因素。迫切需要进一步的研究来确认这种关联并探索潜在的生物学机制。临床医生应认识到性激素在肺纤维化病因中的潜在影响，并在患者管理过程中考虑这一方面。
■我们对PubMed进行了全面搜索，Embase,科克伦图书馆,和WebofScience数据库，以查找截至2024年4月发表的相关研究。我们纳入了报道性激素与肺纤维化风险之间关联的研究。使用随机效应模型计算具有95％置信区间（CI）的标准化平均差（SMD）。
■共十篇，涵盖1371名患者，最终纳入本荟萃分析。根据对纳入研究的评估，观察到硫酸脱氢表雄酮（DHEA-S）的水平（合并SMD：-0.72，95％CI：-1.21至-0.24，p<0.001），肺纤维化患者的睾酮（合并SMD：-1.25，CI：-2.39和-0.11，p<0.001）和雌激素（合并SMD：-0.56，95％CI：-0.96至-0.15，p<0.001）显着降低，而黄体生成素（LH）水平未受影响。通过漏斗图排除了出版偏倚。
■这项荟萃分析表明DHEA-S水平降低，睾丸激素，雌激素可能是肺纤维化的潜在危险因素。迫切需要进一步的研究来确认这种关联并探索潜在的生物学机制。临床医生应认识到性激素在肺纤维化病因中的潜在影响，并在患者管理过程中考虑这一方面。
