PDF(Pubmed)
Abstract：
Rheumatoid arthritis, an inflammatory rheumatic disease predominantly affecting small limb joints, frequently compromises the cervical spine, resulting in spinal instability and the potential surgical necessity. This may result in severe complications, such as ventriculitis, often associated with a high mortality rate and multidrug-resistant organisms. A major challenge lies in achieving therapeutic antimicrobial concentrations in the central nervous system. The authors present a case of a 65-year-old female, with cervical myelopathy due to severe rheumatoid arthritis. Following surgery, the patient developed ventriculitis caused by an extensively drug-resistant Pseudomonas Aeruginosa. Early diagnosis and prompt treatment played a crucial role in facilitating neurological and cognitive recovery.
摘要：
类风湿性关节炎,主要影响肢体关节的炎症性风湿性疾病，经常损害颈椎，导致脊柱不稳定和潜在的手术必要性。这可能会导致严重的并发症，比如脑室炎,通常与高死亡率和多重耐药生物有关。主要挑战在于在中枢神经系统中实现治疗性抗微生物浓度。作者提出了一个65岁女性的案例，严重的类风湿性关节炎导致的脊髓型颈椎病。手术后,患者出现由广泛耐药的铜绿假单胞菌引起的脑室炎.早期诊断和及时治疗在促进神经和认知恢复中起着至关重要的作用。
