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Abstract：
UNASSIGNED: Polycystic ovary syndrome (PCOS) is an endocrine metabolic disorder in reproductive-aged women. The study was designed to investigate the metabolic characteristics of different phenotypes in women with PCOS of reproductive age.
UNASSIGNED: A total of 442 women with PCOS were recruited in this cross-sectional study. According to different phenotypes, all women were divided into three groups: the chronic ovulatory dysfunction and hyperandrogenism group (OD-HA group, n = 138), the chronic ovulatory dysfunction and polycystic ovarian morphology group (OD-PCOM group, n = 161), and the hyperandrogenism and polycystic ovarian morphology group (HA-PCOM group, n = 143). The metabolic risk factors and prevalence rates of metabolic disorders among the three groups were compared.
UNASSIGNED: The body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) of women from the OD-HA group and HA-PCOM group were significantly higher than those of women from the OD-PCOM group (p < 0.05). The serum insulin concentration and homeostasis model assessment of insulin resistance (HOMA IR) at 2 h and 3 h after oral glucose powder in women from the OD-HA group and HA-PCOM group were significantly higher than those from the OD-PCOM group (p < 0.05). The serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in women from the OD-HA group and HA-PCOM group were significantly higher than those in women from the OD-PCOM group (p < 0.05). The prevalence rates of impaired glucose tolerance (IGT), type 2 diabetes mellitus (T2DM), insulin resistance (IR), metabolic syndrome (MS), nonalcoholic fatty liver disease (NAFLD), and dyslipidemia of women with PCOS were 17.9%, 3.6%, 58.4%, 29.4%, 46.6%, and 43.4%, respectively. The prevalence rates of IGT, IR, MS, NAFLD, and dyslipidemia of women in the OD-HA group and HA-PCOM group were significantly higher than those of women in the OD-PCOM group (p < 0.05). T concentration (>1.67 nmol/L) and Ferriman-Gallwey (F-G) score (>3) significantly increased the risk of metabolic disorders in women with PCOS (p < 0.05).
UNASSIGNED: The phenotypes of OD-HA and HA-PCOM in women with PCOS were vulnerable to metabolic disorders compared to OD-PCOM. Thus, the metabolic disorders in women with PCOS especially those with the HA phenotype should be paid more attention in order to reduce long-term complications.
UNASSIGNED: A total of 442 women with PCOS were recruited in this cross-sectional study. According to different phenotypes, all women were divided into three groups: the chronic ovulatory dysfunction and hyperandrogenism group (OD-HA group, n = 138), the chronic ovulatory dysfunction and polycystic ovarian morphology group (OD-PCOM group, n = 161), and the hyperandrogenism and polycystic ovarian morphology group (HA-PCOM group, n = 143). The metabolic risk factors and prevalence rates of metabolic disorders among the three groups were compared.
UNASSIGNED: The body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) of women from the OD-HA group and HA-PCOM group were significantly higher than those of women from the OD-PCOM group (p < 0.05). The serum insulin concentration and homeostasis model assessment of insulin resistance (HOMA IR) at 2 h and 3 h after oral glucose powder in women from the OD-HA group and HA-PCOM group were significantly higher than those from the OD-PCOM group (p < 0.05). The serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in women from the OD-HA group and HA-PCOM group were significantly higher than those in women from the OD-PCOM group (p < 0.05). The prevalence rates of impaired glucose tolerance (IGT), type 2 diabetes mellitus (T2DM), insulin resistance (IR), metabolic syndrome (MS), nonalcoholic fatty liver disease (NAFLD), and dyslipidemia of women with PCOS were 17.9%, 3.6%, 58.4%, 29.4%, 46.6%, and 43.4%, respectively. The prevalence rates of IGT, IR, MS, NAFLD, and dyslipidemia of women in the OD-HA group and HA-PCOM group were significantly higher than those of women in the OD-PCOM group (p < 0.05). T concentration (>1.67 nmol/L) and Ferriman-Gallwey (F-G) score (>3) significantly increased the risk of metabolic disorders in women with PCOS (p < 0.05).
UNASSIGNED: The phenotypes of OD-HA and HA-PCOM in women with PCOS were vulnerable to metabolic disorders compared to OD-PCOM. Thus, the metabolic disorders in women with PCOS especially those with the HA phenotype should be paid more attention in order to reduce long-term complications.
摘要：
■多囊卵巢综合征（PCOS）是育龄期妇女的一种内分泌代谢紊乱。本研究旨在探讨育龄期PCOS女性不同表型的代谢特征。
■这项横断面研究共招募了442名PCOS患者。根据不同的表型,将所有女性分为三组:慢性排卵功能障碍和高雄激素血症组(OD-HA组,n=138),慢性排卵功能障碍和多囊卵巢形态学组(OD-PCOM组,n=161),和高雄激素血症和多囊卵巢形态学组（HA-PCOM组，n=143)。比较3组患者的代谢危险因素和代谢紊乱患病率。
■体重指数（BMI），腰围,OD-HA组和HA-PCOM组的女性的腰臀比（WHR）明显高于OD-PCOM组的女性（p<0.05）。OD-HA组和HA-PCOM组女性口服葡萄糖粉后2h和3h的血清胰岛素浓度和胰岛素抵抗稳态模型评估（HOMAIR）均明显高于OD-PCOM组（p<0.05）。血清总胆固醇(TC),甘油三酯（TG），OD-HA组和HA-PCOM组女性的低密度脂蛋白胆固醇（LDL-C）明显高于OD-PCOM组女性（p<0.05）。糖耐量受损(IGT)的患病率2型糖尿病（T2DM），胰岛素抵抗（IR），代谢综合征（MS），非酒精性脂肪性肝病（NAFLD），PCOS女性的血脂异常占17.9%，3.6%,58.4%,29.4%,46.6%,和43.4%，分别。IGT的患病率,IR,MS,NAFLD,OD-HA组和HA-PCOM组妇女血脂异常明显高于OD-PCOM组妇女（p<0.05）。T浓度(>1.67nmol/L)和Ferriman-Gallwey(F-G)评分(>3)显著增加PCOS患者代谢紊乱的风险(p<0.05)。
■与OD-PCOM相比，患有PCOS的女性中OD-HA和HA-PCOM的表型易受代谢紊乱的影响。因此，PCOS女性尤其是HA表型女性的代谢紊乱应引起更多关注,以减少长期并发症.
■这项横断面研究共招募了442名PCOS患者。根据不同的表型,将所有女性分为三组:慢性排卵功能障碍和高雄激素血症组(OD-HA组,n=138),慢性排卵功能障碍和多囊卵巢形态学组(OD-PCOM组,n=161),和高雄激素血症和多囊卵巢形态学组（HA-PCOM组，n=143)。比较3组患者的代谢危险因素和代谢紊乱患病率。
■体重指数（BMI），腰围,OD-HA组和HA-PCOM组的女性的腰臀比（WHR）明显高于OD-PCOM组的女性（p<0.05）。OD-HA组和HA-PCOM组女性口服葡萄糖粉后2h和3h的血清胰岛素浓度和胰岛素抵抗稳态模型评估（HOMAIR）均明显高于OD-PCOM组（p<0.05）。血清总胆固醇(TC),甘油三酯（TG），OD-HA组和HA-PCOM组女性的低密度脂蛋白胆固醇（LDL-C）明显高于OD-PCOM组女性（p<0.05）。糖耐量受损(IGT)的患病率2型糖尿病（T2DM），胰岛素抵抗（IR），代谢综合征（MS），非酒精性脂肪性肝病（NAFLD），PCOS女性的血脂异常占17.9%，3.6%,58.4%,29.4%,46.6%,和43.4%，分别。IGT的患病率,IR,MS,NAFLD,OD-HA组和HA-PCOM组妇女血脂异常明显高于OD-PCOM组妇女（p<0.05）。T浓度(>1.67nmol/L)和Ferriman-Gallwey(F-G)评分(>3)显著增加PCOS患者代谢紊乱的风险(p<0.05)。
■与OD-PCOM相比，患有PCOS的女性中OD-HA和HA-PCOM的表型易受代谢紊乱的影响。因此，PCOS女性尤其是HA表型女性的代谢紊乱应引起更多关注,以减少长期并发症.
