PDF(Pubmed)
Abstract：
UNASSIGNED: To analyze the clinical and laboratory characteristics and to identify predictors of moderate to severe anti-tuberculosis drug-induced liver injury (ATB-DILI) in patients with tuberculosis.
UNASSIGNED: This prospective study enrolled Tuberculosis (TB) patients treated with first-line anti-tuberculosis drugs at the Affiliated Hospital of Zunyi Medical University between May 2022 and June 2023. The occurrence of ATB-DILI was monitored, and demographic and clinical data were gathered. We analyzed risk factors for the development of moderate to severe ATB-DILI.
UNASSIGNED: ATB-DILI was detected in 120 (10.7%) of the patients, with moderate to severe ATB-DILI occurring in 23 (2.0%) of the 1,124 patients treated with anti-tuberculosis treatment. Multivariate cox regression analysis identified malnutrition (HR = 4.564, 95% CI: 1.029-20.251, p = 0.046) and hemoglobin levels <120 g/L (HR = 2.825, 95% CI: 1.268-11.540, p = 0.017) as independent risk factors for moderate to severe ATB-DILI.
UNASSIGNED: The incidence of moderate to severe ATB-DILI was found to be 2.0%. Malnutrition and hemoglobin levels below 120 g/L emerged as significant independent risk factors for the occurrence of moderate to severe ATB-DILI in this patient population.
UNASSIGNED: This prospective study enrolled Tuberculosis (TB) patients treated with first-line anti-tuberculosis drugs at the Affiliated Hospital of Zunyi Medical University between May 2022 and June 2023. The occurrence of ATB-DILI was monitored, and demographic and clinical data were gathered. We analyzed risk factors for the development of moderate to severe ATB-DILI.
UNASSIGNED: ATB-DILI was detected in 120 (10.7%) of the patients, with moderate to severe ATB-DILI occurring in 23 (2.0%) of the 1,124 patients treated with anti-tuberculosis treatment. Multivariate cox regression analysis identified malnutrition (HR = 4.564, 95% CI: 1.029-20.251, p = 0.046) and hemoglobin levels <120 g/L (HR = 2.825, 95% CI: 1.268-11.540, p = 0.017) as independent risk factors for moderate to severe ATB-DILI.
UNASSIGNED: The incidence of moderate to severe ATB-DILI was found to be 2.0%. Malnutrition and hemoglobin levels below 120 g/L emerged as significant independent risk factors for the occurrence of moderate to severe ATB-DILI in this patient population.
摘要：
■分析结核病患者的临床和实验室特征，并确定中重度抗结核药物引起的肝损伤（ATB-DILI）的预测因子。
■这项前瞻性研究纳入了2022年5月至2023年6月在遵义医科大学附属医院接受一线抗结核药物治疗的结核病（TB）患者。监测ATB-DILI的发生，收集人口统计学和临床数据.我们分析了中度至重度ATB-DILI发展的危险因素。
■在120例（10.7％）患者中检测到ATB-DILI，在1,124例接受抗结核治疗的患者中，有23例（2.0％）发生中度至重度ATB-DILI。多因素cox回归分析确定营养不良（HR=4.564，95％CI：1.029-20.251，p=0.046）和血红蛋白水平<120g/L（HR=2.825，95％CI：1.268-11.540，p=0.017）是中重度ATB-DILI的独立危险因素。
■发现中度至重度ATB-DILI的发生率为2.0％。营养不良和血红蛋白水平低于120g/L是该患者人群中至重度ATB-DILI发生的重要独立危险因素。
■这项前瞻性研究纳入了2022年5月至2023年6月在遵义医科大学附属医院接受一线抗结核药物治疗的结核病（TB）患者。监测ATB-DILI的发生，收集人口统计学和临床数据.我们分析了中度至重度ATB-DILI发展的危险因素。
■在120例（10.7％）患者中检测到ATB-DILI，在1,124例接受抗结核治疗的患者中，有23例（2.0％）发生中度至重度ATB-DILI。多因素cox回归分析确定营养不良（HR=4.564，95％CI：1.029-20.251，p=0.046）和血红蛋白水平<120g/L（HR=2.825，95％CI：1.268-11.540，p=0.017）是中重度ATB-DILI的独立危险因素。
■发现中度至重度ATB-DILI的发生率为2.0％。营养不良和血红蛋白水平低于120g/L是该患者人群中至重度ATB-DILI发生的重要独立危险因素。
