{Reference Type}: Journal Article
{Title}: Clinical risk factors for moderate and severe antituberculosis drug-induced liver injury.
{Author}: Liu Q;Huang L;Yan H;Zong Z;Chen Z;Wu X;Chen L;Lan Y;
{Journal}: Front Pharmacol
{Volume}: 15
{Issue}: 0
{Year}: 2024
{Factor}: 5.988
{DOI}: 10.3389/fphar.2024.1406454
{Abstract}: <B>UNASSIGNED: </B>To analyze the clinical and laboratory characteristics and to identify predictors of moderate to severe anti-tuberculosis drug-induced liver injury (ATB-DILI) in patients with tuberculosis.<BR><B>UNASSIGNED: </B>This prospective study enrolled Tuberculosis (TB) patients treated with first-line anti-tuberculosis drugs at the Affiliated Hospital of Zunyi Medical University between May 2022 and June 2023. The occurrence of ATB-DILI was monitored, and demographic and clinical data were gathered. We analyzed risk factors for the development of moderate to severe ATB-DILI.<BR><B>UNASSIGNED: </B>ATB-DILI was detected in 120 (10.7%) of the patients, with moderate to severe ATB-DILI occurring in 23 (2.0%) of the 1,124 patients treated with anti-tuberculosis treatment. Multivariate cox regression analysis identified malnutrition (HR = 4.564, 95% CI: 1.029-20.251, p = 0.046) and hemoglobin levels <120 g/L (HR = 2.825, 95% CI: 1.268-11.540, p = 0.017) as independent risk factors for moderate to severe ATB-DILI.<BR><B>UNASSIGNED: </B>The incidence of moderate to severe ATB-DILI was found to be 2.0%. Malnutrition and hemoglobin levels below 120 g/L emerged as significant independent risk factors for the occurrence of moderate to severe ATB-DILI in this patient population.