PDF(Pubmed)
Abstract：
UNASSIGNED: Pediatric bronchopneumonia is a prevalent life-threatening disease, particularly in developing countries. Affordable and accessible blood biomarkers are needed to predict disease severity which can be based on the Duration of Hospitalization (DOH).
UNASSIGNED: To assess the significance and correlation between differential blood profiles, especially the Neutrophil-Lymphocyte Ratio (NLR), and the DOH in bronchopneumonia children.
UNASSIGNED: A record-based study was conducted at a secondary care hospital in Indonesia. After due ethical permission, following inclusion and exclusion criteria, 284 children with confirmed diagnoses of bronchopneumonia were included in the study. Blood cell counts and ratios were assessed with the DOH as the main criterion of severity. Mann-Whitney test and correlation coefficient were used to draw an analysis.
UNASSIGNED: Study samples were grouped into DOH of ≤ 4 days and > 4 days, focusing on NLR values, neutrophils, lymphocytes, and leukocytes. The NLR median was higher (3.98) in patients hospitalized over 4 days (P<0.0001). Lymphocyte medians were significantly higher in the opposite group (P<0.0001). Thrombocyte medians were similar in both groups (P=0.44481). The overall NLR and DOH were weakly positively correlated, with a moderate positive correlation in total neutrophils and DOH, and a moderate negative correlation in total lymphocytes and DOH. The correlation between the DOH ≤ 4 days group with each biomarker was stronger, except for leukocyte and thrombocyte. Analysis of the longer DOH group did not yield enough correlation across all blood counts.
UNASSIGNED: Admission levels of leukocyte count, neutrophil, lymphocyte, and NLR significantly correlate with the DOH, with NLR predicting severity and positively correlated with the DOH.
UNASSIGNED: To assess the significance and correlation between differential blood profiles, especially the Neutrophil-Lymphocyte Ratio (NLR), and the DOH in bronchopneumonia children.
UNASSIGNED: A record-based study was conducted at a secondary care hospital in Indonesia. After due ethical permission, following inclusion and exclusion criteria, 284 children with confirmed diagnoses of bronchopneumonia were included in the study. Blood cell counts and ratios were assessed with the DOH as the main criterion of severity. Mann-Whitney test and correlation coefficient were used to draw an analysis.
UNASSIGNED: Study samples were grouped into DOH of ≤ 4 days and > 4 days, focusing on NLR values, neutrophils, lymphocytes, and leukocytes. The NLR median was higher (3.98) in patients hospitalized over 4 days (P<0.0001). Lymphocyte medians were significantly higher in the opposite group (P<0.0001). Thrombocyte medians were similar in both groups (P=0.44481). The overall NLR and DOH were weakly positively correlated, with a moderate positive correlation in total neutrophils and DOH, and a moderate negative correlation in total lymphocytes and DOH. The correlation between the DOH ≤ 4 days group with each biomarker was stronger, except for leukocyte and thrombocyte. Analysis of the longer DOH group did not yield enough correlation across all blood counts.
UNASSIGNED: Admission levels of leukocyte count, neutrophil, lymphocyte, and NLR significantly correlate with the DOH, with NLR predicting severity and positively correlated with the DOH.
摘要：
■小儿支气管肺炎是一种普遍的危及生命的疾病，特别是在发展中国家。需要负担得起的和可获得的血液生物标志物来预测疾病严重程度，这可以基于住院时间（DOH）。
■为了评估差异血液谱之间的显著性和相关性，特别是中性粒细胞-淋巴细胞比率(NLR)，和支气管肺炎儿童的DOH。
一项基于记录的研究在印度尼西亚的二级保健医院进行。经过应有的道德许可，遵循纳入和排除标准，本研究纳入了284例确诊为支气管肺炎的儿童。以DOH作为严重程度的主要标准来评估血细胞计数和比率。采用Mann-Whitney检验和相关系数进行分析。
■将研究样品分为≤4天和>4天的DOH，专注于NLR值，中性粒细胞，淋巴细胞，和白细胞。住院超过4天的患者的NLR中位数较高（3.98）（P<0.0001）。淋巴细胞介质显著高于对照组(P<0.0001)。两组的血小板介质相似(P=0.44481)。总体NLR和DOH呈弱正相关，中性粒细胞和DOH呈中度正相关，总淋巴细胞和DOH呈中度负相关。DOH≤4天组与各生物标志物之间的相关性更强，除了白细胞和血小板。较长DOH组的分析在所有血细胞计数中没有产生足够的相关性。
■白细胞计数的入院水平，中性粒细胞,淋巴细胞，NLR与DOH显着相关，NLR可预测严重程度，并与DOH呈正相关。
■为了评估差异血液谱之间的显著性和相关性，特别是中性粒细胞-淋巴细胞比率(NLR)，和支气管肺炎儿童的DOH。
一项基于记录的研究在印度尼西亚的二级保健医院进行。经过应有的道德许可，遵循纳入和排除标准，本研究纳入了284例确诊为支气管肺炎的儿童。以DOH作为严重程度的主要标准来评估血细胞计数和比率。采用Mann-Whitney检验和相关系数进行分析。
■将研究样品分为≤4天和>4天的DOH，专注于NLR值，中性粒细胞，淋巴细胞，和白细胞。住院超过4天的患者的NLR中位数较高（3.98）（P<0.0001）。淋巴细胞介质显著高于对照组(P<0.0001)。两组的血小板介质相似(P=0.44481)。总体NLR和DOH呈弱正相关，中性粒细胞和DOH呈中度正相关，总淋巴细胞和DOH呈中度负相关。DOH≤4天组与各生物标志物之间的相关性更强，除了白细胞和血小板。较长DOH组的分析在所有血细胞计数中没有产生足够的相关性。
■白细胞计数的入院水平，中性粒细胞,淋巴细胞，NLR与DOH显着相关，NLR可预测严重程度，并与DOH呈正相关。
