PDF(Pubmed)
Abstract：
UNASSIGNED: Deep brain stimulation of the nucleus ventralis intermedius (VIM-DBS) is considered a safe and effective treatment for medically intractable essential tremor (ET). However, ventriculomegaly can provide a surgical challenge, as there is an increased risk of breaching the ventricle during the procedure, with potential risk of intraventricular hemorrhage and target displacement.
UNASSIGNED: In this case series, we report successful bilateral VIM-DBS in a 72-year-old and 69-year-old female ET patient with significant ventriculomegaly. VIM-DBS therapy provided an excellent tremor response. After 5 years, a ventriculoperitoneal shunt was implanted in the first patient due to an incomplete Hakim-Adams triad, with significant improvement in gait and cognition.
UNASSIGNED: To the best of our knowledge, we present the first report on VIM-DBS in ET patients with ventriculomegaly and illustrate that VIM-DBS can provide an excellent tremor response in patients with medically intractable ET, even in the context of marked ventriculomegaly.
UNASSIGNED: In this case series, we report successful bilateral VIM-DBS in a 72-year-old and 69-year-old female ET patient with significant ventriculomegaly. VIM-DBS therapy provided an excellent tremor response. After 5 years, a ventriculoperitoneal shunt was implanted in the first patient due to an incomplete Hakim-Adams triad, with significant improvement in gait and cognition.
UNASSIGNED: To the best of our knowledge, we present the first report on VIM-DBS in ET patients with ventriculomegaly and illustrate that VIM-DBS can provide an excellent tremor response in patients with medically intractable ET, even in the context of marked ventriculomegaly.
摘要：
■腹核的深部脑刺激（VIM-DBS）被认为是治疗医学上顽固性特发性震颤（ET）的安全有效的治疗方法。然而,脑室肿大可以提供手术挑战，因为在手术过程中心室破裂的风险增加，具有脑室内出血和靶移位的潜在风险。
■在这种情况下，我们报道了1例72岁和69岁女性ET患者成功的双侧VIM-DBS,患者有显著的脑室增宽.VIM-DBS治疗提供了优异的震颤反应。五年后,由于Hakim-Adams三联征不完整，第一位患者植入了脑室-腹腔分流术，步态和认知的显著改善。
■据我们所知,我们首次报道了VIM-DBS在患有脑室增宽的ET患者中的应用，并阐明了VIM-DBS可以为患有难治性ET的患者提供良好的震颤反应。即使在明显的脑室增宽的情况下。
■在这种情况下，我们报道了1例72岁和69岁女性ET患者成功的双侧VIM-DBS,患者有显著的脑室增宽.VIM-DBS治疗提供了优异的震颤反应。五年后,由于Hakim-Adams三联征不完整，第一位患者植入了脑室-腹腔分流术，步态和认知的显著改善。
■据我们所知,我们首次报道了VIM-DBS在患有脑室增宽的ET患者中的应用，并阐明了VIM-DBS可以为患有难治性ET的患者提供良好的震颤反应。即使在明显的脑室增宽的情况下。
