关键词: Drug metabolism drug transport high-altitude hypoxia rational use of drugs. sedative-hypnotics sleep disorders

来  源:   DOI:10.2174/0113892002318723240802100729

Abstract:
Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impacting medication therapy\'s effectiveness. This review aims to provide a theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of high-altitude hypoxia on sleep.
摘要:
镇静催眠药通过降低中枢神经系统兴奋性,有效改善高原低氧下的睡眠质量。高原缺氧会导致睡眠障碍,并改变药物的代谢和作用机制,影响药物治疗的有效性。本综述旨在通过总结低氧环境下镇静催眠药的研究进展及机制,为高海拔地区中枢神经系统疾病的治疗提供理论依据。以及高原缺氧对睡眠的影响。
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