%0 Journal Article
%T Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism.
%A Tian L
%A Liu G
%A Han J
%A Li X
%J Curr Drug Metab
%V 0
%N 0
%D 2024 08 6
%M 39108116
%F 3.408
%R 10.2174/0113892002318723240802100729
%X Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impacting medication therapy's effectiveness. This review aims to provide a theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of high-altitude hypoxia on sleep.