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Abstract：
Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both structure and function, and they more precisely resemble the morphology and cellular structure of the human embryonic brain. This makes them valuable models for both drug screening and in vitro studies on the development of the human brain and associated disorders. The technical breakthroughs enabled by brain organoids have a significant impact on the research of different brain regions, brain development and sickness, the connections between the brain and other tissues and organs, and brain evolution. This article discusses the development of brain organoids, their use in diabetes research, and their progress.
摘要：
人胚胎干细胞和人诱导多能干细胞可用于创建称为脑类器官的3D组织。它们在结构和功能两方面更忠实地复制了人脑组织的生理和病理特征,它们更精确地类似于人类胚胎大脑的形态和细胞结构。这使它们成为有价值的模型，用于药物筛选和关于人脑和相关疾病发展的体外研究。脑类器官实现的技术突破对不同脑区的研究产生了重大影响，大脑发育和疾病，大脑与其他组织和器官之间的联系，和大脑进化。本文讨论了脑类器官的发育，它们在糖尿病研究中的应用，和他们的进步。
