METHODS: Relevant cases were extracted from the prospectively collected database of all LTs performed in our center. All clinical variables, details of the perioperative course of each patient and long-term follow-up data were thoroughly assessed.
RESULTS: Between January 2000 and August 2023, 2703 LTs were carried out. Among them, six patients underwent LT for PHLF, which accounted for 0.2% of all patients. The median age of the patients was 38 years (range 24-66 years). All patients underwent major liver resection before listing for LT. The 90-day mortality after LT was 66.7% (4 out of 6 patients), and all patients experienced complications in the posttransplant course. One patient required early retransplantation due to primary non-function (PNF). The last two transplanted patients are alive at 7 years and 12 months after LT, respectively.
CONCLUSIONS: In an unselected population of patients with PHLF, LT is a very morbid procedure associated with high mortality but should be considered the only life-saving option in this group.
方法:从前瞻性收集的在我们中心进行的所有LTs的数据库中提取相关病例。所有临床变量,我们对每位患者的围手术期细节和长期随访数据进行了全面评估.
结果:在2000年1月至2023年8月之间,进行了2703LTs。其中,六名患者接受了PHLFLT,占所有患者的0.2%。患者的中位年龄为38岁(范围24-66岁)。所有患者在上市前进行了肝脏大切除术。LT术后90天死亡率为66.7%(6例患者中有4例),所有患者在移植后的过程中都出现了并发症。一名患者由于原发性无功能(PNF)而需要早期再移植。最后两名移植患者在LT术后7年12个月存活,分别。
结论:在未选择的PHLF患者人群中,LT是一种与高死亡率相关的非常病态的手术,但应该被认为是该组中唯一的挽救生命的选择。