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Abstract：
BACKGROUND: Premature coronary artery disease (PCAD) is prevailing. We aimed to investigate the evaluation value of atherogenic index of plasma (AIP) and high-sensitivity C-reactive protein (hs-CRP) for the occurrence and severity of coronary artery lesion in PCAD patients.
METHODS: PCAD (PACD group)/non-PCAD (control group) patients were enrolled. The coronary artery lesion degree was evaluated using Gensini score (GS). PCAD patients were allocated into the low/medium/high GS groups, with general clinical baseline data analyzed. Plasma hs-CRP/AIP levels were compared in PCAD patients with different disease degree. Correlations between plasma hs-CRP/AIP with Gensini score, independent risk factors affecting the occurrence of PCAD, and the predictive value of hs-CRP/AIP/their combination for the occurrence and degree of PCAD were evaluated by Spearman correlation analysis/Logistic multivariate regression/receiver operating characteristic (ROC) curve. The differences in the area under the curve (AUC) were compared using MedCalc-Comparison of ROC curves.
RESULTS: Plasma hs-CRP/AIP levels in the PCAD group were increased. Plasma hs-CRP/AIP levels varied significantly among PCAD patients with different disease degree. Plasma hs-CRP/AIP levels were markedly positively correlated with the Gensini score. Smoking history/homocysteine/fasting blood-glucose/hs-CRP/AIP were all independent risk factors affecting PCAD occurrence. The AUC of hs-CRP and AIP combination predicting the occurrence of PCAD was 0.950 (90.80% sensitivity/93.33% specificity). hs-CRP/AIP combination assisted in predicting the disease degree in PCAD patients.
CONCLUSIONS: AIP and hs-CRP are independent risk factors for the occurrence of PCAD, and their combination has high predictive value for PCAD occurrence and disease degree, which are both positively correlated with coronary artery lesion degree.
METHODS: PCAD (PACD group)/non-PCAD (control group) patients were enrolled. The coronary artery lesion degree was evaluated using Gensini score (GS). PCAD patients were allocated into the low/medium/high GS groups, with general clinical baseline data analyzed. Plasma hs-CRP/AIP levels were compared in PCAD patients with different disease degree. Correlations between plasma hs-CRP/AIP with Gensini score, independent risk factors affecting the occurrence of PCAD, and the predictive value of hs-CRP/AIP/their combination for the occurrence and degree of PCAD were evaluated by Spearman correlation analysis/Logistic multivariate regression/receiver operating characteristic (ROC) curve. The differences in the area under the curve (AUC) were compared using MedCalc-Comparison of ROC curves.
RESULTS: Plasma hs-CRP/AIP levels in the PCAD group were increased. Plasma hs-CRP/AIP levels varied significantly among PCAD patients with different disease degree. Plasma hs-CRP/AIP levels were markedly positively correlated with the Gensini score. Smoking history/homocysteine/fasting blood-glucose/hs-CRP/AIP were all independent risk factors affecting PCAD occurrence. The AUC of hs-CRP and AIP combination predicting the occurrence of PCAD was 0.950 (90.80% sensitivity/93.33% specificity). hs-CRP/AIP combination assisted in predicting the disease degree in PCAD patients.
CONCLUSIONS: AIP and hs-CRP are independent risk factors for the occurrence of PCAD, and their combination has high predictive value for PCAD occurrence and disease degree, which are both positively correlated with coronary artery lesion degree.
摘要：
背景：早发冠状动脉疾病（PCAD）普遍存在。目的探讨血浆致动脉粥样硬化指数(AIP)和超敏C反应蛋白(hs-CRP)对PCAD患者冠状动脉病变发生及严重程度的评估价值。
方法：纳入PCAD（PACD组）/非PCAD（对照组）患者。采用Gensini评分(GS)评价冠状动脉病变程度。将PCAD患者分为低/中/高GS组，分析一般临床基线数据。比较不同程度PCAD患者血浆hs-CRP/AIP水平。血浆hs-CRP/AIP与Gensini评分的相关性,影响PCAD发生的独立危险因素，采用Spearman相关分析/Logistic多元回归/受试者工作特征(ROC)曲线评价hs-CRP/AIP/组合对PCAD发生及程度的预测价值。使用MedCalc-比较ROC曲线比较曲线下面积(AUC)的差异。
结果：PCAD组血浆hs-CRP/AIP水平升高。不同程度PCAD患者血浆hs-CRP/AIP水平存在显著差异。血浆hs-CRP/AIP水平与Gensini评分呈显著正相关。吸烟史/同型半胱氨酸/空腹血糖/hs-CRP/AIP均为影响PCAD发生的独立危险因素。hs-CRP和AIP联合预测PCAD发生的AUC为0.950(90.80%敏感性/93.33%特异性)。hs-CRP/AIP联合应用有助于预测PCAD患者的病情程度.
结论：AIP和hs-CRP是PCAD发生的独立危险因素。两者联合对PCAD的发生和疾病程度有较高的预测价值，两者均与冠状动脉病变程度呈正相关。
方法：纳入PCAD（PACD组）/非PCAD（对照组）患者。采用Gensini评分(GS)评价冠状动脉病变程度。将PCAD患者分为低/中/高GS组，分析一般临床基线数据。比较不同程度PCAD患者血浆hs-CRP/AIP水平。血浆hs-CRP/AIP与Gensini评分的相关性,影响PCAD发生的独立危险因素，采用Spearman相关分析/Logistic多元回归/受试者工作特征(ROC)曲线评价hs-CRP/AIP/组合对PCAD发生及程度的预测价值。使用MedCalc-比较ROC曲线比较曲线下面积(AUC)的差异。
结果：PCAD组血浆hs-CRP/AIP水平升高。不同程度PCAD患者血浆hs-CRP/AIP水平存在显著差异。血浆hs-CRP/AIP水平与Gensini评分呈显著正相关。吸烟史/同型半胱氨酸/空腹血糖/hs-CRP/AIP均为影响PCAD发生的独立危险因素。hs-CRP和AIP联合预测PCAD发生的AUC为0.950(90.80%敏感性/93.33%特异性)。hs-CRP/AIP联合应用有助于预测PCAD患者的病情程度.
结论：AIP和hs-CRP是PCAD发生的独立危险因素。两者联合对PCAD的发生和疾病程度有较高的预测价值，两者均与冠状动脉病变程度呈正相关。
