Abstract：
Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a biologically and prognostically heterogeneous B cell lymphoma that frequently involves the bone marrow, with interstitial, nodular-paratrabecular, or diffuse patterns. Intrasinusoidal bone marrow involvement has been described only anecdotally in this lymphoma. Here, we describe the clinical, histopathological, and molecular features of four patients diagnosed with advanced-stage mantle cell lymphoma, showing intrasinusoidal bone marrow involvement, and other peculiar immunophenotypical features. As similar cases may represent a relevant issue in bone marrow diagnostic histopathology, we also reviewed the literature to discuss differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement.
摘要：
在有限数量的B和T细胞淋巴瘤中观察到的静脉内骨髓受累是罕见的组织学模式。套细胞淋巴瘤是一种生物学和预后异质性B细胞淋巴瘤，通常涉及骨髓，有间隙，结节性旁分子,或扩散模式。在这种淋巴瘤中，仅有轶事地描述了静脉内骨髓受累。这里,我们描述了临床，组织病理学,和四名诊断为晚期套细胞淋巴瘤的患者的分子特征，显示静脉内骨髓受累，和其他特殊的免疫表型特征。由于类似病例可能代表骨髓诊断组织病理学的相关问题，我们还回顾了文献，以讨论伴有窦内骨髓受累的B和T细胞淋巴瘤的鉴别诊断。
