METHODS: Data were accessed from the Parkinson\'s Progression Markers Initiative (PPMI) project. Connectometry analyses were performed for GBA1+ PD, LRRK2+ PD, and sporadic PD correlating white matter structural changes, as measured by quantitative anisotropy (QA), with motor impairment, as measured by MDS-UPDRS III.
RESULTS: There was a negative correlation between QA and MDS-UPDRS III in all 3 cohorts at 48 months. In GBA1+ PD (n = 12), the white matter tracts identified were cortical and subcortical, while in the LRRK2+ PD (n = 18) and sporadic PD (n = 45) cohorts white tracts identified were primarily subcortical and within the brainstem.
CONCLUSIONS: Our findings highlight the association between motor symptom progrerssion and structural connectivity in individuals with GBA1+ PD, LRRK2+ PD, and sporadic PD. Due to the small sample size, larger studies are needed in the future to confirm the findings.
方法:数据来自帕金森进展标志物倡议(PPMI)项目。对GBA1+PD进行了Connectometry分析,LRRK2+PD,和与白质结构变化相关的零星PD,如通过定量各向异性(QA)测量的,有运动障碍,通过MDS-UPDRSIII测量。
结果:在48个月的所有3个队列中,QA和MDS-UPDRSIII之间均呈负相关。在GBA1+PD(n=12)中,确定的白质束是皮质和皮质下,而在LRRK2PD(n=18)和散发性PD(n=45)队列中,确定的白色束主要是皮质下和脑干内。
结论:我们的研究结果强调了GBA1+PD患者运动症状进展与结构连通性之间的关联,LRRK2+PD,和零星的PD。由于样本量小,未来需要更大的研究来证实这些发现。