Abstract：
UNASSIGNED: To identify factors affecting functional hearing performance and quality of life (QoL) outcomes in paediatric cochlear implantation (CI) recipients at two University centres in mainland China.
UNASSIGNED: Two university centres in mainland China, part of the prospective longitudinal Paediatric Implanted Recipient Observational Study (P-IROS), contributed participant data. Participants were aged under 10 years at time of CI. Functional hearing performance and QoL measures were collected prior to device activation, and at 6-monthly intervals for 2 years post-implantation. Functional hearing endpoints including Categories of Auditory Performance-II (CAP-II) and QoL were evaluated and analysed using ordinal mixed-effects regression models.
UNASSIGNED: Data were from 288 children with a mean age at implant of 2.74 years. Overall follow-up at 1 year was 59% and 51% at 2 years. Younger age at implantation (p<0.001) and hearing aid use preimplantation (p=0.026) were associated with significant benefit. Bilateral device users (both CI and bimodal) achieved significantly better functional hearing performance on the CAP-II than unilateral CI users (p<0.001). Slower functional hearing improvements were observed in those with lower parental expectations compared to higher expectations (p<0.001). QoL improved over time but followed a different initial trajectory between centres.
UNASSIGNED: All participants demonstrated significant improvements in auditory performance and QoL over time. Younger age at CI, and bilateral/bimodal device fitting contributed to earlier improvements. Other potential factors that could help inform families, professionals, and health authorities about choice of hearing device and educational supports required included aetiology of hearing loss and level of maternal education.
UNASSIGNED: Two university centres in mainland China, part of the prospective longitudinal Paediatric Implanted Recipient Observational Study (P-IROS), contributed participant data. Participants were aged under 10 years at time of CI. Functional hearing performance and QoL measures were collected prior to device activation, and at 6-monthly intervals for 2 years post-implantation. Functional hearing endpoints including Categories of Auditory Performance-II (CAP-II) and QoL were evaluated and analysed using ordinal mixed-effects regression models.
UNASSIGNED: Data were from 288 children with a mean age at implant of 2.74 years. Overall follow-up at 1 year was 59% and 51% at 2 years. Younger age at implantation (p<0.001) and hearing aid use preimplantation (p=0.026) were associated with significant benefit. Bilateral device users (both CI and bimodal) achieved significantly better functional hearing performance on the CAP-II than unilateral CI users (p<0.001). Slower functional hearing improvements were observed in those with lower parental expectations compared to higher expectations (p<0.001). QoL improved over time but followed a different initial trajectory between centres.
UNASSIGNED: All participants demonstrated significant improvements in auditory performance and QoL over time. Younger age at CI, and bilateral/bimodal device fitting contributed to earlier improvements. Other potential factors that could help inform families, professionals, and health authorities about choice of hearing device and educational supports required included aetiology of hearing loss and level of maternal education.
摘要：
■确定影响功能性听力表现和生活质量（QoL）结果的因素在中国大陆两个大学中心的儿科人工耳蜗植入（CI）接受者。
■中国大陆的两个大学中心，前瞻性纵向儿科植入受体观察性研究（P-IROS）的一部分，贡献的参与者数据。在CI时，参与者的年龄在10岁以下。在设备激活前收集功能性听力表现和QoL测量值。植入后2年，间隔6个月。使用序数混合效应回归模型评估和分析了功能性听力终点，包括听觉表现-II（CAP-II）和QoL类别。
■数据来自288名平均年龄为2.74岁的儿童。1年的总体随访率为59%，2年为51%。植入时年龄较小（p<0.001）和植入前使用助听器（p=0.026）与显着益处相关。在CAP-II上，双侧设备用户（同时使用CI和双峰）的功能听力明显优于单侧CI用户（p<0.001）。与父母期望较高的期望相比，父母期望较低的人的听力功能改善较慢（p<0.001）。QoL随着时间的推移而改善，但在中心之间遵循不同的初始轨迹。
■随着时间的推移，所有参与者都表现出听觉表现和QoL的显着改善。年龄较小的atCI和双侧/双峰装置拟合有助于早期改善。其他可能有助于告知家庭的潜在因素，专业人士,卫生当局关于听力设备的选择和所需的教育支持包括听力损失的病因和母亲教育水平。
■中国大陆的两个大学中心，前瞻性纵向儿科植入受体观察性研究（P-IROS）的一部分，贡献的参与者数据。在CI时，参与者的年龄在10岁以下。在设备激活前收集功能性听力表现和QoL测量值。植入后2年，间隔6个月。使用序数混合效应回归模型评估和分析了功能性听力终点，包括听觉表现-II（CAP-II）和QoL类别。
■数据来自288名平均年龄为2.74岁的儿童。1年的总体随访率为59%，2年为51%。植入时年龄较小（p<0.001）和植入前使用助听器（p=0.026）与显着益处相关。在CAP-II上，双侧设备用户（同时使用CI和双峰）的功能听力明显优于单侧CI用户（p<0.001）。与父母期望较高的期望相比，父母期望较低的人的听力功能改善较慢（p<0.001）。QoL随着时间的推移而改善，但在中心之间遵循不同的初始轨迹。
■随着时间的推移，所有参与者都表现出听觉表现和QoL的显着改善。年龄较小的atCI和双侧/双峰装置拟合有助于早期改善。其他可能有助于告知家庭的潜在因素，专业人士,卫生当局关于听力设备的选择和所需的教育支持包括听力损失的病因和母亲教育水平。
