Abstract：
OBJECTIVE: Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are rare, aggressive thyroid cancers with poor prognosis. At present, there are a limited number of research reports on PDTC and ATC. The study aimed to analysis the predictive value of hematologic parameters and clinicopathological features of PDTC and ATC.
METHODS: This study retrospectively analyzed 67 patients at Tianjin Medical University Cancer Hospital from 2007 to 2019. We analyzed the clinicopathological features and survival outcomes of PDTC and ATC.
RESULTS: This study showed that positive D-dimer, a high NLR, and a high PLR were more common in death patients. At the end of follow-up, 22 (32.8%) patients were alive at the time of study and 45 (67.2%) patients died from thyroid carcinoma. Disease-related death rates were 93.8% in ATC and 42.9% in the PDTC group. The median overall survival (OS) was 2.5 (0.3-84) months for patients with ATC, and 56 (3-113) months of PDTC patients. Univariate analysis showed that age at diagnosis and surgery were associations with OS in ATC patients, what\'s more, age at diagnosis, a high NLR, a high PLR, and positive D-dimer were associations with OS in PDTC patients. Multivariate analysis revealed that age at diagnosis was an independent association with OS in ATC patients.
CONCLUSIONS: The hematologic parameters and clinicopathological features may provide predictive value of prognosis for patients with PTDC and ATC.
METHODS: This study retrospectively analyzed 67 patients at Tianjin Medical University Cancer Hospital from 2007 to 2019. We analyzed the clinicopathological features and survival outcomes of PDTC and ATC.
RESULTS: This study showed that positive D-dimer, a high NLR, and a high PLR were more common in death patients. At the end of follow-up, 22 (32.8%) patients were alive at the time of study and 45 (67.2%) patients died from thyroid carcinoma. Disease-related death rates were 93.8% in ATC and 42.9% in the PDTC group. The median overall survival (OS) was 2.5 (0.3-84) months for patients with ATC, and 56 (3-113) months of PDTC patients. Univariate analysis showed that age at diagnosis and surgery were associations with OS in ATC patients, what\'s more, age at diagnosis, a high NLR, a high PLR, and positive D-dimer were associations with OS in PDTC patients. Multivariate analysis revealed that age at diagnosis was an independent association with OS in ATC patients.
CONCLUSIONS: The hematologic parameters and clinicopathological features may provide predictive value of prognosis for patients with PTDC and ATC.
摘要：
目的：低分化甲状腺癌（PDTC）和间变性甲状腺癌（ATC）是罕见的，侵袭性甲状腺癌预后差。目前,关于PDTC和ATC的研究报告数量有限。本研究旨在分析PDTC和ATC的血液学参数和临床病理特征的预测价值。
方法：本研究对2007-2019年天津医科大学附属肿瘤医院67例患者进行回顾性分析。我们分析了PDTC和ATC的临床病理特征和生存结果。
结果：本研究显示D-二聚体阳性，高NLR,高PLR在死亡患者中更为常见。在后续行动结束时，在研究时，22例（32.8％）患者存活，45例（67.2％）患者死于甲状腺癌。ATC和PDTC组的疾病相关死亡率分别为93.8%和42.9%。ATC患者的中位总生存期（OS）为2.5（0.3-84）个月，和56（3-113）个月的PDTC患者。单因素分析显示，ATC患者的诊断年龄和手术年龄与OS相关，更重要的是，诊断时的年龄，高NLR,高PLR,D-二聚体阳性与PDTC患者OS相关。多因素分析显示，ATC患者的诊断年龄与OS独立相关。
结论：血液学参数和临床病理特征可能为PTDC和ATC患者的预后提供预测价值。
方法：本研究对2007-2019年天津医科大学附属肿瘤医院67例患者进行回顾性分析。我们分析了PDTC和ATC的临床病理特征和生存结果。
结果：本研究显示D-二聚体阳性，高NLR,高PLR在死亡患者中更为常见。在后续行动结束时，在研究时，22例（32.8％）患者存活，45例（67.2％）患者死于甲状腺癌。ATC和PDTC组的疾病相关死亡率分别为93.8%和42.9%。ATC患者的中位总生存期（OS）为2.5（0.3-84）个月，和56（3-113）个月的PDTC患者。单因素分析显示，ATC患者的诊断年龄和手术年龄与OS相关，更重要的是，诊断时的年龄，高NLR,高PLR,D-二聚体阳性与PDTC患者OS相关。多因素分析显示，ATC患者的诊断年龄与OS独立相关。
结论：血液学参数和临床病理特征可能为PTDC和ATC患者的预后提供预测价值。
