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Abstract：
This review explores the pivotal role of angiogenesis in breast cancer progression and treatment. It covers biomarkers, imaging techniques, therapeutic approaches, resistance mechanisms, and clinical implications. Key topics include Vascular Endothelial Growth Factors, angiopoietins, microRNA signatures, and circulating endothelial cells as biomarkers, along with Magnetic Resonance Imaging, Computed Tomography Angiography, Ultrasound, and Positron Emission Tomography for imaging. Therapeutic strategies targeting VEGF, tyrosine kinase inhibitors, and the intersection of angiogenesis with immunotherapy are discussed. Challenges such as resistance mechanisms and personalized medicine approaches are addressed. Clinical implications, prognostic value, and the future direction of angiogenesis-targeted therapies are highlighted. The article concludes with reflections on the transformative potential of understanding angiogenesis.
摘要：
本文就血管生成在乳腺癌进展和治疗中的关键作用作一综述。它涵盖了生物标志物，成像技术，治疗方法，抵抗机制，和临床意义。关键主题包括血管内皮生长因子，血管生成素,microRNA签名,循环内皮细胞作为生物标志物，随着磁共振成像，CT血管造影,超声波,和正电子发射断层扫描成像。靶向VEGF的治疗策略,酪氨酸激酶抑制剂，并讨论了血管生成与免疫治疗的交叉。解决了诸如抗性机制和个性化医疗方法等挑战。临床意义，预后价值，并强调了血管生成靶向治疗的未来方向。本文最后对理解血管生成的转化潜力进行了思考。
