METHODS: A comprehensive search was conducted across databases including PubMed, Embase, Scopus, and Web of Science up to June 2024. Data from the included studies were synthesized using a meta-analytical approach with a random-effects model, assessing heterogeneity with the I2 and Tau-squared indices.
RESULTS: We included 17 studies in this systematic review. The meta-analysis, which included data from eight studies reporting CP volume relative to TIV, found a statistically significant increase in CP volume in MS patients compared to healthy controls (HCs). The SMD was 0.77 (95% CI: 0.61 to 0.93), indicating a large effect size. This analysis showed no heterogeneity (I² = 0%). A separate meta-analysis was conducted using five studies that reported CP volume as normalized volume, resulting in an SMD of 0.63 (95% CI: 0.2-1.06).
CONCLUSIONS: This study demonstrates an increase in CP volume among MS patients compared to HCs, implying the potential involvement of CP in MS pathogenesis and/or progression. These results show that CP might serve as a radiological indicator in the diagnosis and prognosis of MS.
方法:对包括PubMed在内的数据库进行了全面搜索,Embase,Scopus,和WebofScience至2024年6月。纳入研究的数据使用荟萃分析方法与随机效应模型进行综合,用I2和Tau平方指数评估异质性。
结果:本系统综述纳入了17项研究。荟萃分析,其中包括来自8项研究的数据,报告CP体积相对于TIV,发现与健康对照组(HC)相比,MS患者的CP体积有统计学意义的增加。SMD为0.77(95%CI:0.61至0.93),表示大的效果大小。该分析表明没有异质性(I²=0%)。使用五项报告CP体积为归一化体积的研究进行了单独的荟萃分析,导致SMD为0.63(95%CI:0.2-1.06)。
结论:这项研究表明,与HCs相比,MS患者的CP体积增加,暗示CP可能参与MS的发病机制和/或进展。这些结果表明,CP可能作为MS诊断和预后的放射学指标。