Abstract：
OBJECTIVE: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the destruction of the myelin sheath within the central nervous system. The etiology of MS involves a complex interplay of genetic, environmental, and immunological factors. Recent studies indicated the potential role of the choroid plexus (CP) in the pathogenesis and progression of MS. This systematic review aims to assess existing research on the volume alterations of the CP in MS patients compared to the normal population.
METHODS: A comprehensive search was conducted across databases including PubMed, Embase, Scopus, and Web of Science up to June 2024. Data from the included studies were synthesized using a meta-analytical approach with a random-effects model, assessing heterogeneity with the I2 and Tau-squared indices.
RESULTS: We included 17 studies in this systematic review. The meta-analysis, which included data from eight studies reporting CP volume relative to TIV, found a statistically significant increase in CP volume in MS patients compared to healthy controls (HCs). The SMD was 0.77 (95% CI: 0.61 to 0.93), indicating a large effect size. This analysis showed no heterogeneity (I² = 0%). A separate meta-analysis was conducted using five studies that reported CP volume as normalized volume, resulting in an SMD of 0.63 (95% CI: 0.2-1.06).
CONCLUSIONS: This study demonstrates an increase in CP volume among MS patients compared to HCs, implying the potential involvement of CP in MS pathogenesis and/or progression. These results show that CP might serve as a radiological indicator in the diagnosis and prognosis of MS.
METHODS: A comprehensive search was conducted across databases including PubMed, Embase, Scopus, and Web of Science up to June 2024. Data from the included studies were synthesized using a meta-analytical approach with a random-effects model, assessing heterogeneity with the I2 and Tau-squared indices.
RESULTS: We included 17 studies in this systematic review. The meta-analysis, which included data from eight studies reporting CP volume relative to TIV, found a statistically significant increase in CP volume in MS patients compared to healthy controls (HCs). The SMD was 0.77 (95% CI: 0.61 to 0.93), indicating a large effect size. This analysis showed no heterogeneity (I² = 0%). A separate meta-analysis was conducted using five studies that reported CP volume as normalized volume, resulting in an SMD of 0.63 (95% CI: 0.2-1.06).
CONCLUSIONS: This study demonstrates an increase in CP volume among MS patients compared to HCs, implying the potential involvement of CP in MS pathogenesis and/or progression. These results show that CP might serve as a radiological indicator in the diagnosis and prognosis of MS.
摘要：
目的：多发性硬化症（MS）是一种慢性自身免疫性疾病，其特征是中枢神经系统内髓鞘的破坏。MS的病因涉及复杂的遗传相互作用，环境,和免疫因素。最近的研究表明脉络丛（CP）在MS的发病机制和进展中的潜在作用。本系统综述旨在评估MS患者与正常人群相比CP体积变化的现有研究。
方法：对包括PubMed在内的数据库进行了全面搜索，Embase,Scopus,和WebofScience至2024年6月。纳入研究的数据使用荟萃分析方法与随机效应模型进行综合，用I2和Tau平方指数评估异质性。
结果：本系统综述纳入了17项研究。荟萃分析，其中包括来自8项研究的数据，报告CP体积相对于TIV，发现与健康对照组（HC）相比，MS患者的CP体积有统计学意义的增加。SMD为0.77（95%CI：0.61至0.93），表示大的效果大小。该分析表明没有异质性(I²=0%)。使用五项报告CP体积为归一化体积的研究进行了单独的荟萃分析，导致SMD为0.63（95%CI：0.2-1.06）。
结论：这项研究表明，与HCs相比，MS患者的CP体积增加，暗示CP可能参与MS的发病机制和/或进展。这些结果表明，CP可能作为MS诊断和预后的放射学指标。
方法：对包括PubMed在内的数据库进行了全面搜索，Embase,Scopus,和WebofScience至2024年6月。纳入研究的数据使用荟萃分析方法与随机效应模型进行综合，用I2和Tau平方指数评估异质性。
结果：本系统综述纳入了17项研究。荟萃分析，其中包括来自8项研究的数据，报告CP体积相对于TIV，发现与健康对照组（HC）相比，MS患者的CP体积有统计学意义的增加。SMD为0.77（95%CI：0.61至0.93），表示大的效果大小。该分析表明没有异质性(I²=0%)。使用五项报告CP体积为归一化体积的研究进行了单独的荟萃分析，导致SMD为0.63（95%CI：0.2-1.06）。
结论：这项研究表明，与HCs相比，MS患者的CP体积增加，暗示CP可能参与MS的发病机制和/或进展。这些结果表明，CP可能作为MS诊断和预后的放射学指标。
