关键词: Histamine-2 receptor antagonist antacid proton pump inhibitor sucralfate

Mesh : Cats Animals Cat Diseases / drug therapy Evidence-Based Medicine Anti-Ulcer Agents / therapeutic use Peptic Ulcer / veterinary drug therapy Esophagitis / veterinary drug therapy

来  源:   DOI:10.1177/1098612X241274235

Abstract:
UNASSIGNED: Acid-related disorders including esophagitis and gastroduodenal ulceration are uncommon in the cat. However, when they occur, they can have devastating consequences and require targeted intervention, including the use of gastroprotectants. Careful consideration of the causes of esophagitis and gastroduodenal ulceration can help the clinician to determine which gastroprotectant to use, and when to begin and end gastroprotective therapy.
UNASSIGNED: Gastroprotectants remain one of the most misused classes of drugs in veterinary and human medicine. There are very few studies evaluating the efficacy of gastroprotective agents in cats. Furthermore, goals for the degree of gastric acid suppression are extrapolated from studies performed in dogs and humans.
UNASSIGNED: This review provides a foundation for the logical approach to the choice of gastroprotectant as indicated by the disease process, and is aimed at all veterinarians who prescribe gastroprotectants for use in cats.
UNASSIGNED: The guidance provided in this review is supported by current literature, including consensus opinion from the American College of Veterinary Internal Medicine. Gaps in evidence for use of gastroprotectants in cats are filled by extrapolations from studies performed in dogs and humans.
摘要:
酸相关疾病包括食管炎和胃十二指肠溃疡在猫中并不常见。然而,当它们发生时,它们可能会产生毁灭性的后果,需要有针对性的干预,包括使用胃保护剂。仔细考虑食管炎和胃十二指肠溃疡的原因可以帮助临床医生确定使用哪种胃保护剂,以及何时开始和结束胃保护疗法。
胃保护剂仍然是兽医学和人类医学中最滥用的药物之一。很少有研究评估胃保护剂在猫中的功效。此外,胃酸抑制程度的目标是从对狗和人类进行的研究中推断出来的.
这篇综述为疾病过程所表明的选择胃保护剂的逻辑方法提供了基础,针对所有为猫开胃保护剂的兽医。
本评论中提供的指导得到了当前文献的支持,包括美国兽医内科学院的共识意见。通过在狗和人类中进行的研究的外推,填补了在猫中使用胃保护剂的证据空白。
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