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Abstract：
BACKGROUND: Loneliness and social isolation have been found to be associated with various health-related outcomes. Our study aimed to evaluate the association of loneliness and social isolation with the risk of glaucoma.
METHODS: A total of 373,330 participants from the UK Biobank without glaucoma at recruitment were included in this study. Self-reported questionnaires were used to define loneliness and social isolation. Incident glaucoma events were identified by hospital inpatient admissions and self-reported data. COX proportional hazards models adjusted for sociodemographic, lifestyle, and health-related factors were used to estimate hazard ratios (HRs) and 95% CIs.
RESULTS: During a median follow-up of 13.1 (interquartile range: 12.3-13.9) years, 6,489 participants developed glaucoma. After adjusting for confounding factors, loneliness (yes vs. no: adjusted HR: 1.16; 95% CI: 1.04-1.30; P = 0.009) and social isolation (yes vs. no: adjusted HR: 1.08; 95% CI: 1.01-1.16; P = 0.033) were associated with an increased risk of glaucoma.
CONCLUSIONS: In this population-based prospective cohort study, loneliness and social isolation were associated with a higher risk of glaucoma.
METHODS: A total of 373,330 participants from the UK Biobank without glaucoma at recruitment were included in this study. Self-reported questionnaires were used to define loneliness and social isolation. Incident glaucoma events were identified by hospital inpatient admissions and self-reported data. COX proportional hazards models adjusted for sociodemographic, lifestyle, and health-related factors were used to estimate hazard ratios (HRs) and 95% CIs.
RESULTS: During a median follow-up of 13.1 (interquartile range: 12.3-13.9) years, 6,489 participants developed glaucoma. After adjusting for confounding factors, loneliness (yes vs. no: adjusted HR: 1.16; 95% CI: 1.04-1.30; P = 0.009) and social isolation (yes vs. no: adjusted HR: 1.08; 95% CI: 1.01-1.16; P = 0.033) were associated with an increased risk of glaucoma.
CONCLUSIONS: In this population-based prospective cohort study, loneliness and social isolation were associated with a higher risk of glaucoma.
摘要：
背景：已发现孤独和社会隔离与各种健康相关结果有关。我们的研究旨在评估孤独感和社会隔离与青光眼风险的关系。
方法：本研究纳入了来自UKBiobank招募时无青光眼的总共373,330名参与者。使用自我报告的问卷来定义孤独和社会孤立。通过住院患者和自我报告的数据确定青光眼事件。针对社会人口统计学调整的COX比例风险模型，生活方式,和健康相关因素用于估计风险比(HRs)和95%CIs。
结果：在13.1（四分位距：12.3-13.9）年的中位随访期间，6,489名参与者发展为青光眼。在调整混杂因素后，孤独（是与否：调整后HR：1.16；95%CI：1.04-1.30；P=0.009）和社会隔离（是与否:校正后HR:1.08;95%CI:1.01-1.16;P=0.033)与青光眼风险增加相关.
结论：在这项基于人群的前瞻性队列研究中，孤独感和社会隔离与较高的青光眼风险相关.
方法：本研究纳入了来自UKBiobank招募时无青光眼的总共373,330名参与者。使用自我报告的问卷来定义孤独和社会孤立。通过住院患者和自我报告的数据确定青光眼事件。针对社会人口统计学调整的COX比例风险模型，生活方式,和健康相关因素用于估计风险比(HRs)和95%CIs。
结果：在13.1（四分位距：12.3-13.9）年的中位随访期间，6,489名参与者发展为青光眼。在调整混杂因素后，孤独（是与否：调整后HR：1.16；95%CI：1.04-1.30；P=0.009）和社会隔离（是与否:校正后HR:1.08;95%CI:1.01-1.16;P=0.033)与青光眼风险增加相关.
结论：在这项基于人群的前瞻性队列研究中，孤独感和社会隔离与较高的青光眼风险相关.
