PDF(Pubmed)
Abstract：
BACKGROUND: COVID-19 infections can result in severe acute respiratory distress syndrome (ARDS) requiring admission to the intensive care unit (ICU). Cardiovascular manifestation or exacerbation of cardiovascular diseases could be another complication. Cardiac arrhythmias including New-Onset Atrial Fibrillation (NOAF), have been observed in hospitalized patients with COVID-19 infections. In this analysis, we aimed to systematically compare the complications associated with NOAF in critically ill COVID-19 patients admitted to the ICU.
METHODS: MEDLINE, EMBASE, Web of Science, the Cochrane database, http://www.
RESULTS: gov , Google Scholar and Mendeley were searched for relevant publications based on COVID-19 patients with NOAF admitted to the ICU. Complications including in-hospital mortality, ICU mortality, patients requiring mechanical ventilation, acute myocardial infarction, acute kidney injury, renal replacement therapy and pulmonary embolism were assessed. This is a meta-analysis and the analytical tool which was used was the RevMan software version 5.4. Risk ratios (RR) and 95% confidence intervals (CIs) were used to represent the data post analysis.
RESULTS: In critically ill COVID-19 patients with NOAF admitted to the ICU, the risks of ICU mortality (RR: 1.39, 95% CI: 1.07 - 1.80; P = 0.01), in-hospital mortality (RR: 1.56, 95% CI: 1.20 - 2.04; P = 0.001), patients requiring mechanical ventilation (RR: 1.32, 95% CI: 1.04 - 1.66; P = 0.02) were significantly higher when compared to the control group without AF. Acute myocardial infarction (RR: 1.54, 95% CI: 1.31 - 1.81; P = 0.00001), the risk for acute kidney injury (RR: 1.31, 95% CI: 1.11 - 1.55; P = 0.002) and patients requiring renal replacement therapy (RR: 1.83, 95% CI: 1.60 - 2.09; P = 0.00001) were also significantly higher in patients with NOAF.
CONCLUSIONS: Critically ill COVID-19 patients with NOAF admitted to the ICU were at significantly higher risks of developing complications and death compared to similar patients without AF.
METHODS: MEDLINE, EMBASE, Web of Science, the Cochrane database, http://www.
RESULTS: gov , Google Scholar and Mendeley were searched for relevant publications based on COVID-19 patients with NOAF admitted to the ICU. Complications including in-hospital mortality, ICU mortality, patients requiring mechanical ventilation, acute myocardial infarction, acute kidney injury, renal replacement therapy and pulmonary embolism were assessed. This is a meta-analysis and the analytical tool which was used was the RevMan software version 5.4. Risk ratios (RR) and 95% confidence intervals (CIs) were used to represent the data post analysis.
RESULTS: In critically ill COVID-19 patients with NOAF admitted to the ICU, the risks of ICU mortality (RR: 1.39, 95% CI: 1.07 - 1.80; P = 0.01), in-hospital mortality (RR: 1.56, 95% CI: 1.20 - 2.04; P = 0.001), patients requiring mechanical ventilation (RR: 1.32, 95% CI: 1.04 - 1.66; P = 0.02) were significantly higher when compared to the control group without AF. Acute myocardial infarction (RR: 1.54, 95% CI: 1.31 - 1.81; P = 0.00001), the risk for acute kidney injury (RR: 1.31, 95% CI: 1.11 - 1.55; P = 0.002) and patients requiring renal replacement therapy (RR: 1.83, 95% CI: 1.60 - 2.09; P = 0.00001) were also significantly higher in patients with NOAF.
CONCLUSIONS: Critically ill COVID-19 patients with NOAF admitted to the ICU were at significantly higher risks of developing complications and death compared to similar patients without AF.
摘要：
背景：COVID-19感染可导致严重急性呼吸窘迫综合征（ARDS），需要入住重症监护病房（ICU）。心血管表现或心血管疾病的恶化可能是另一种并发症。心律失常，包括新发心房颤动（NOAF），在COVID-19感染的住院患者中观察到。在这个分析中,我们旨在系统地比较入住ICU的危重COVID-19患者与NOAF相关的并发症.
方法：MEDLINE，EMBASE,WebofScience,Cochrane数据库,http://www。
结果：政府，根据入住ICU的NOAFCOVID-19患者，搜索了GoogleScholar和Mendeley的相关出版物。并发症包括住院死亡率，ICU死亡率，需要机械通气的患者，急性心肌梗死,急性肾损伤，评估了肾脏替代治疗和肺栓塞.这是荟萃分析,使用的分析工具是RevMan软件版本5.4。使用风险比（RR）和95％置信区间（CI）表示分析后的数据。
结果：在入住ICU的重症COVID-19NOAF患者中，ICU死亡风险（RR：1.39，95%CI：1.07-1.80；P=0.01），住院死亡率（RR：1.56，95%CI：1.20-2.04；P=0.001），需要机械通气的患者(RR:1.32,95%CI:1.04-1.66;P=0.02)与无AF的对照组相比,明显较高.急性心肌梗死(RR:1.54,95%CI:1.31-1.81;P=0.00001),急性肾损伤的风险(RR:1.31,95%CI:1.11-1.55;P=0.002)和需要肾脏替代治疗的患者(RR:1.83,95%CI:1.60-2.09;P=0.00001)也显著高于NOAF患者.
结论：入住ICU的患有NOAF的重症COVID-19患者发生并发症和死亡的风险明显高于无AF的类似患者。
方法：MEDLINE，EMBASE,WebofScience,Cochrane数据库,http://www。
结果：政府，根据入住ICU的NOAFCOVID-19患者，搜索了GoogleScholar和Mendeley的相关出版物。并发症包括住院死亡率，ICU死亡率，需要机械通气的患者，急性心肌梗死,急性肾损伤，评估了肾脏替代治疗和肺栓塞.这是荟萃分析,使用的分析工具是RevMan软件版本5.4。使用风险比（RR）和95％置信区间（CI）表示分析后的数据。
结果：在入住ICU的重症COVID-19NOAF患者中，ICU死亡风险（RR：1.39，95%CI：1.07-1.80；P=0.01），住院死亡率（RR：1.56，95%CI：1.20-2.04；P=0.001），需要机械通气的患者(RR:1.32,95%CI:1.04-1.66;P=0.02)与无AF的对照组相比,明显较高.急性心肌梗死(RR:1.54,95%CI:1.31-1.81;P=0.00001),急性肾损伤的风险(RR:1.31,95%CI:1.11-1.55;P=0.002)和需要肾脏替代治疗的患者(RR:1.83,95%CI:1.60-2.09;P=0.00001)也显著高于NOAF患者.
结论：入住ICU的患有NOAF的重症COVID-19患者发生并发症和死亡的风险明显高于无AF的类似患者。
