PDF(Pubmed)
Abstract：
Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud\'s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere\'s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP recorded as the extent of finger blanching calculated with Griffin score, (2) vibration perception thresholds, (3) magnitude of current exposure as [A(8); (m/s2)] value, and (4) the duration of exposure in years. Serum levels of thrombomodulin, von Willebrand factor, calcitonin gene related peptide (CGRP), heat shock protein 27, and caspase-3 were positively associated with severity of RP. Serum levels of CGRP were positively associated with the neurosensory component. No associations with exposure were shown for these biomarkers. For Intercellular adhesion molecule 1 and monocyte chemoattractant protein 1, no associations were found with neither severity nor exposure. Levels of serum biomarkers associated with endothelial injury or dysfunction, inflammation, vasodilation, neuroprotection, and apoptosis were positively associated with the severity of hand-arm vibration injury.
摘要：
我们的目的是探索患者血清生物标志物水平与血管严重程度之间的关系。即，雷诺现象（RP），和神经感觉表现，当前的暴露水平，和暴露的持续时间。本研究采用病例系列设计，涉及92例诊断为手臂振动损伤的患者。Jonckheere的趋势检验用于评估血清生物标志物水平与RP以及神经感觉表现之间的任何关联。按国际共识标准分级。对可能的混杂因素进行调整的广义线性模型也用于生物标志物的血清水平之间的关联；（1）RP的严重程度记录为手指漂白的程度，用Griffin评分计算，(2)振动感知阈值,（3）电流暴露的幅度为[A（8）；（m/s2）]值，和（4）暴露的持续时间，以年为单位。血清血栓调节蛋白水平,vonWillebrand因子,降钙素基因相关肽（CGRP），热休克蛋白27和caspase-3与RP的严重程度呈正相关。血清CGRP水平与神经感觉成分呈正相关。对于这些生物标志物,未显示与暴露的关联。对于细胞间粘附分子1和单核细胞趋化蛋白1，未发现与严重程度或暴露无关。与内皮损伤或功能障碍相关的血清生物标志物水平，炎症,血管舒张,神经保护,细胞凋亡与手臂振动损伤的严重程度呈正相关。
