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Abstract：
BACKGROUND: Leprosy affects various organs in addition to skin, eyes, and peripheral nerves. Testicular involvement in leprosy patients is common and causes disturbance in endocrine function of the testis and results in hypogonadism. Hypogonadism is frequently undiagnosed and underreported.
OBJECTIVE: This study aimed to assess hypogonadism and associated factors among leprosy patients at Alert Comprehensive Specialized Hospital, Ethiopia.
METHODS: A cross-sectional study design was used in which consecutive 146 male leprosy patients aged between 18 to 65 years attending outpatient follow-up at leprosy outpatient clinic were included. Data was gathered both from patient charts and through patients\' interviews. Androgen deficiency symptoms were assessed by androgen deficiency in the aging male questionnaire, and 5ml of blood samples were taken from study participants and serum total testosterone, LH, and FSH were analyzed by Electrochemiluminescence method. Statistical correlation was assessed by Spearman correlation. A multivariable binary logistic regression model was used to identify the independent factors associated with hypogonadism and P-value <0.05 was used to declare statistical significance.
RESULTS: The prevalence of hypogonadism was 39 (26.7%). Out of this, 34 (87.2%) had primary hypogonadism, whereas 5 (12.8%) had secondary hypogonadism. Total testosterone was inversely correlated with Body mass index (r = -0.37, p = 0.002), Luteinizing hormone (r = -0.43, p <0.001), and Follicular stimulating hormone (r = -0.42, p< 0.001). However, Total testosterone was not significantly correlated with age (r = -0.019, p = 0.81). BMI [AOR = 1.32, 95%CI (1.16-1.51)] and grade-II disability [AOR = 3.80, 95%CI (1.23-11.64)] were identified as independent risk factors for hypogonadism.
CONCLUSIONS: Nearly one-fourth of male leprosy patients had hypogonadism. Overweight and grade-II disability were independent risk factors for hypogonadism.
OBJECTIVE: This study aimed to assess hypogonadism and associated factors among leprosy patients at Alert Comprehensive Specialized Hospital, Ethiopia.
METHODS: A cross-sectional study design was used in which consecutive 146 male leprosy patients aged between 18 to 65 years attending outpatient follow-up at leprosy outpatient clinic were included. Data was gathered both from patient charts and through patients\' interviews. Androgen deficiency symptoms were assessed by androgen deficiency in the aging male questionnaire, and 5ml of blood samples were taken from study participants and serum total testosterone, LH, and FSH were analyzed by Electrochemiluminescence method. Statistical correlation was assessed by Spearman correlation. A multivariable binary logistic regression model was used to identify the independent factors associated with hypogonadism and P-value <0.05 was used to declare statistical significance.
RESULTS: The prevalence of hypogonadism was 39 (26.7%). Out of this, 34 (87.2%) had primary hypogonadism, whereas 5 (12.8%) had secondary hypogonadism. Total testosterone was inversely correlated with Body mass index (r = -0.37, p = 0.002), Luteinizing hormone (r = -0.43, p <0.001), and Follicular stimulating hormone (r = -0.42, p< 0.001). However, Total testosterone was not significantly correlated with age (r = -0.019, p = 0.81). BMI [AOR = 1.32, 95%CI (1.16-1.51)] and grade-II disability [AOR = 3.80, 95%CI (1.23-11.64)] were identified as independent risk factors for hypogonadism.
CONCLUSIONS: Nearly one-fourth of male leprosy patients had hypogonadism. Overweight and grade-II disability were independent risk factors for hypogonadism.
摘要：
背景：麻风病影响除皮肤外的各种器官，眼睛,和周围神经。麻风病患者的睾丸受累很常见，会导致睾丸内分泌功能紊乱，并导致性腺机能减退。性腺功能减退症经常未被诊断和报道。
目的：本研究旨在评估Alert综合专科医院麻风患者的性腺功能减退及相关因素，埃塞俄比亚。
方法：采用横断面研究设计，纳入146名年龄在18至65岁之间的男性麻风病患者，在麻风病门诊进行门诊随访。数据来自患者图表和患者访谈。雄激素缺乏症状通过老年男性问卷中的雄激素缺乏进行评估，从研究参与者和血清总睾酮中抽取5ml血液样本，LH,采用电化学发光法对FSH和FSH进行分析。通过Spearman相关性评估统计相关性。使用多变量二元逻辑回归模型来确定与性腺功能减退症相关的独立因素，并使用P值<0.05来说明有统计学意义。
结果：性腺功能减退症的患病率为39（26.7%）。出了这个,34人（87.2%）患有原发性性腺功能减退症，而5例(12.8%)有继发性性腺功能减退症。总睾酮与体重指数呈负相关(r=-0.37,p=0.002),促黄体生成素(r=-0.43,p<0.001),和卵泡刺激素（r=-0.42，p<0.001）。然而,总睾酮与年龄无显著相关性(r=-0.019,p=0.81)。BMI[AOR=1.32，95CI（1.16-1.51）]和II级残疾[AOR=3.80，95CI（1.23-11.64）]是性腺功能减退的独立危险因素。
结论：近四分之一的男性麻风病人有性腺功能减退症。超重和II级残疾是性腺功能减退症的独立危险因素。
目的：本研究旨在评估Alert综合专科医院麻风患者的性腺功能减退及相关因素，埃塞俄比亚。
方法：采用横断面研究设计，纳入146名年龄在18至65岁之间的男性麻风病患者，在麻风病门诊进行门诊随访。数据来自患者图表和患者访谈。雄激素缺乏症状通过老年男性问卷中的雄激素缺乏进行评估，从研究参与者和血清总睾酮中抽取5ml血液样本，LH,采用电化学发光法对FSH和FSH进行分析。通过Spearman相关性评估统计相关性。使用多变量二元逻辑回归模型来确定与性腺功能减退症相关的独立因素，并使用P值<0.05来说明有统计学意义。
结果：性腺功能减退症的患病率为39（26.7%）。出了这个,34人（87.2%）患有原发性性腺功能减退症，而5例(12.8%)有继发性性腺功能减退症。总睾酮与体重指数呈负相关(r=-0.37,p=0.002),促黄体生成素(r=-0.43,p<0.001),和卵泡刺激素（r=-0.42，p<0.001）。然而,总睾酮与年龄无显著相关性(r=-0.019,p=0.81)。BMI[AOR=1.32，95CI（1.16-1.51）]和II级残疾[AOR=3.80，95CI（1.23-11.64）]是性腺功能减退的独立危险因素。
结论：近四分之一的男性麻风病人有性腺功能减退症。超重和II级残疾是性腺功能减退症的独立危险因素。
