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Abstract：
BACKGROUND: Postherpetic neuralgia (PHN) is a classic chronic condition with multiple signs of peripheral and central neuropathy. Unfortunately, the pathogenesis of PHN is not well defined, limiting clinical treatment and disease management.
OBJECTIVE: To describe the peripheral and central pathological axes of PHN, including peripheral nerve injury, inflammation induction, central nervous system sensitization, and brain functional and structural network activity.
METHODS: A bibliographic survey was carried out, selecting relevant articles that evaluated the characterization of the pathogenesis of PHN, including peripheral and central pathological axes.
RESULTS: Currently, due to the complexity of the pathophysiological mechanisms of PHN and the incomplete understanding of the exact mechanism of neuralgia.
CONCLUSIONS: It is essential to conduct in-depth research to clarify the origins of PHN pathogenesis and explore effective and comprehensive therapies for PHN.
OBJECTIVE: To describe the peripheral and central pathological axes of PHN, including peripheral nerve injury, inflammation induction, central nervous system sensitization, and brain functional and structural network activity.
METHODS: A bibliographic survey was carried out, selecting relevant articles that evaluated the characterization of the pathogenesis of PHN, including peripheral and central pathological axes.
RESULTS: Currently, due to the complexity of the pathophysiological mechanisms of PHN and the incomplete understanding of the exact mechanism of neuralgia.
CONCLUSIONS: It is essential to conduct in-depth research to clarify the origins of PHN pathogenesis and explore effective and comprehensive therapies for PHN.
摘要：
背景：带状疱疹后遗神经痛（PHN）是一种经典的慢性疾病，具有多种外周和中枢神经病变的体征。不幸的是,PHN的发病机制尚不明确，限制临床治疗和疾病管理。
目的：描述PHN的外周和中心病理轴，包括周围神经损伤,炎症诱导，中枢神经系统致敏，和大脑功能和结构网络活动。
方法：进行了书目调查，选择评估PHN发病机理表征的相关文章，包括外周和中枢病理轴。
结果：目前，由于PHN病理生理机制的复杂性和对神经痛确切机制的不完全理解。
结论：有必要进行深入研究，以阐明PHN发病机制的起源，并探索有效和全面的治疗PHN的方法。
目的：描述PHN的外周和中心病理轴，包括周围神经损伤,炎症诱导，中枢神经系统致敏，和大脑功能和结构网络活动。
方法：进行了书目调查，选择评估PHN发病机理表征的相关文章，包括外周和中枢病理轴。
结果：目前，由于PHN病理生理机制的复杂性和对神经痛确切机制的不完全理解。
结论：有必要进行深入研究，以阐明PHN发病机制的起源，并探索有效和全面的治疗PHN的方法。
