OBJECTIVE: To describe the peripheral and central pathological axes of PHN, including peripheral nerve injury, inflammation induction, central nervous system sensitization, and brain functional and structural network activity.
METHODS: A bibliographic survey was carried out, selecting relevant articles that evaluated the characterization of the pathogenesis of PHN, including peripheral and central pathological axes.
RESULTS: Currently, due to the complexity of the pathophysiological mechanisms of PHN and the incomplete understanding of the exact mechanism of neuralgia.
CONCLUSIONS: It is essential to conduct in-depth research to clarify the origins of PHN pathogenesis and explore effective and comprehensive therapies for PHN.
目的:描述PHN的外周和中心病理轴,包括周围神经损伤,炎症诱导,中枢神经系统致敏,和大脑功能和结构网络活动。
方法:进行了书目调查,选择评估PHN发病机理表征的相关文章,包括外周和中枢病理轴。
结果:目前,由于PHN病理生理机制的复杂性和对神经痛确切机制的不完全理解。
结论:有必要进行深入研究,以阐明PHN发病机制的起源,并探索有效和全面的治疗PHN的方法。