{Reference Type}: Journal Article
{Title}: Peripheral and central pathogenesis of postherpetic neuralgia.
{Author}: Liu Q;Han J;Zhang X;
{Journal}: Skin Res Technol
{Volume}: 30
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 2.24
{DOI}: 10.1111/srt.13867
{Abstract}: <B>BACKGROUND: </B>Postherpetic neuralgia (PHN) is a classic chronic condition with multiple signs of peripheral and central neuropathy. Unfortunately, the pathogenesis of PHN is not well defined, limiting clinical treatment and disease management.<BR><B>OBJECTIVE: </B>To describe the peripheral and central pathological axes of PHN, including peripheral nerve injury, inflammation induction, central nervous system sensitization, and brain functional and structural network activity.<BR><B>METHODS: </B>A bibliographic survey was carried out, selecting relevant articles that evaluated the characterization of the pathogenesis of PHN, including peripheral and central pathological axes.<BR><B>RESULTS: </B>Currently, due to the complexity of the pathophysiological mechanisms of PHN and the incomplete understanding of the exact mechanism of neuralgia.<BR><B>CONCLUSIONS: </B>It is essential to conduct in-depth research to clarify the origins of PHN pathogenesis and explore effective and comprehensive therapies for PHN.