PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the association between visceral obesity and glycemic control in patients with type 2 diabetes mellitus.
UNASSIGNED: A retrospective analysis involved 714 patients diagnosed with type 2 diabetes mellitus from the National Metabolic Management Center from November 2021 to February 2024. Medical data included sociodemographic data, lifestyle behaviors, and anthropometric and biochemical measurements. Multivariate logistic regression analysis was used to analyze their associations.
UNASSIGNED: Among the patients, 251 (35.2%) achieved good glycemic control (HbA1c < 7.0%). On univariate analysis, higher diastolic blood pressure, longer duration of type 2 diabetes mellitus, tobacco smoking, alcohol drinking, insulin treatment, higher levels of fasting plasma glucose, homeostasis model assessment of insulin resistance, triglyceride, total cholesterol, and low-density lipoprotein cholesterol, visceral obesity (visceral fat area ≥ 100cm2) and diabetic peripheral neuropathy were all positively correlated with poor glycemic control; female, older age, higher levels of C peptide and serum uric acid were inversely associated with poor glycemic control (all P < 0.05). On multivariate logistic regression analysis, the results suggested that higher diastolic blood pressure [OR: 1.021, 95% CI (1.002, 1.040), P = 0.030], insulin treatment [currently used: OR = 2.156, 95% CI (1.249, 3.724), P = 0.006], higher level of fasting plasma glucose [OR: 1.819, 95% CI (1.598, 2.069), P < 0.001], and visceral obesity [OR: 1.876, 95% CI (1.158, 3.038), P = 0.011] were risk factors for poor glycemic control.
UNASSIGNED: This study indicated that visceral obesity (visceral fat area ≥ 100cm2) is positively associated with poor glycemic control, and serves as an independent risk factor for poor glycemic control (HbA1c ≥ 7.0%) in patients with type 2 diabetes mellitus. Screening for visceral obesity should be emphasized, and targeted interventions should be taken to improve glycemic control in patients with type 2 diabetes mellitus.
UNASSIGNED: A retrospective analysis involved 714 patients diagnosed with type 2 diabetes mellitus from the National Metabolic Management Center from November 2021 to February 2024. Medical data included sociodemographic data, lifestyle behaviors, and anthropometric and biochemical measurements. Multivariate logistic regression analysis was used to analyze their associations.
UNASSIGNED: Among the patients, 251 (35.2%) achieved good glycemic control (HbA1c < 7.0%). On univariate analysis, higher diastolic blood pressure, longer duration of type 2 diabetes mellitus, tobacco smoking, alcohol drinking, insulin treatment, higher levels of fasting plasma glucose, homeostasis model assessment of insulin resistance, triglyceride, total cholesterol, and low-density lipoprotein cholesterol, visceral obesity (visceral fat area ≥ 100cm2) and diabetic peripheral neuropathy were all positively correlated with poor glycemic control; female, older age, higher levels of C peptide and serum uric acid were inversely associated with poor glycemic control (all P < 0.05). On multivariate logistic regression analysis, the results suggested that higher diastolic blood pressure [OR: 1.021, 95% CI (1.002, 1.040), P = 0.030], insulin treatment [currently used: OR = 2.156, 95% CI (1.249, 3.724), P = 0.006], higher level of fasting plasma glucose [OR: 1.819, 95% CI (1.598, 2.069), P < 0.001], and visceral obesity [OR: 1.876, 95% CI (1.158, 3.038), P = 0.011] were risk factors for poor glycemic control.
UNASSIGNED: This study indicated that visceral obesity (visceral fat area ≥ 100cm2) is positively associated with poor glycemic control, and serves as an independent risk factor for poor glycemic control (HbA1c ≥ 7.0%) in patients with type 2 diabetes mellitus. Screening for visceral obesity should be emphasized, and targeted interventions should be taken to improve glycemic control in patients with type 2 diabetes mellitus.
摘要：
■探讨2型糖尿病患者内脏肥胖与血糖控制的关系。
■回顾性分析涉及2021年11月至2024年2月从国家代谢管理中心诊断为2型糖尿病的714例患者。医疗数据包括社会人口统计数据，生活方式行为，以及人体测量和生化测量。采用多因素logistic回归分析其相关性。
■在患者中，251（35.2%）血糖控制良好（HbA1c<7.0%）。在单变量分析中，更高的舒张压,2型糖尿病的持续时间较长，吸烟,饮酒,胰岛素治疗，空腹血糖水平较高，胰岛素抵抗的稳态模型评估，甘油三酯，总胆固醇,低密度脂蛋白胆固醇,内脏肥胖(内脏脂肪面积≥100cm2)和糖尿病周围神经病变均与血糖控制不良呈正相关;女性,年龄较大,C肽和血尿酸水平升高与血糖控制不良呈负相关(均P<0.05)。在多元逻辑回归分析中，结果表明，舒张压[OR：1.021，95%CI（1.002，1.040），P=0.030],胰岛素治疗[目前使用：OR=2.156，95%CI（1.249，3.724），P=0.006],空腹血糖水平较高[OR：1.819，95%CI（1.598，2.069），P<0.001],和内脏肥胖[OR：1.876，95%CI（1.158，3.038），P=0.011]是血糖控制不良的危险因素。
■这项研究表明，内脏肥胖（内脏脂肪面积≥100cm2）与血糖控制不良正相关，并作为2型糖尿病患者血糖控制不良（HbA1c≥7.0%）的独立危险因素。应强调内脏肥胖的筛查，应采取针对性干预措施改善2型糖尿病患者的血糖控制。
■回顾性分析涉及2021年11月至2024年2月从国家代谢管理中心诊断为2型糖尿病的714例患者。医疗数据包括社会人口统计数据，生活方式行为，以及人体测量和生化测量。采用多因素logistic回归分析其相关性。
■在患者中，251（35.2%）血糖控制良好（HbA1c<7.0%）。在单变量分析中，更高的舒张压,2型糖尿病的持续时间较长，吸烟,饮酒,胰岛素治疗，空腹血糖水平较高，胰岛素抵抗的稳态模型评估，甘油三酯，总胆固醇,低密度脂蛋白胆固醇,内脏肥胖(内脏脂肪面积≥100cm2)和糖尿病周围神经病变均与血糖控制不良呈正相关;女性,年龄较大,C肽和血尿酸水平升高与血糖控制不良呈负相关(均P<0.05)。在多元逻辑回归分析中，结果表明，舒张压[OR：1.021，95%CI（1.002，1.040），P=0.030],胰岛素治疗[目前使用：OR=2.156，95%CI（1.249，3.724），P=0.006],空腹血糖水平较高[OR：1.819，95%CI（1.598，2.069），P<0.001],和内脏肥胖[OR：1.876，95%CI（1.158，3.038），P=0.011]是血糖控制不良的危险因素。
■这项研究表明，内脏肥胖（内脏脂肪面积≥100cm2）与血糖控制不良正相关，并作为2型糖尿病患者血糖控制不良（HbA1c≥7.0%）的独立危险因素。应强调内脏肥胖的筛查，应采取针对性干预措施改善2型糖尿病患者的血糖控制。
