PDF(Pubmed)
Abstract：
UNASSIGNED: Human brucellosis, caused by the bacteria Brucella, is a significant infectious disease globally, also known as Mediterranean fever or Malta fever.
UNASSIGNED: This meta-analysis and systematic review focuses on the prevalence rate, risk factors, and diagnostic methods of human brucellosis in Middle Eastern countries, where the disease remains a significant public health issue. The analysis included 92 studies conducted between 1993 and 2024, following specified inclusion and exclusion criteria among symptomatic patients across these countries. The prevalence rate was calculated by dividing positive samples by total samples. The I2 index and Chi-squared test assessed study heterogeneity. Significant heterogeneity occurred when I2 exceeded 50 %.
UNASSIGNED: The highest prevalence rate was observed in Oman, Lebanon, and Kuwait countries, emphasizing a notable burden of Brucella infection in these regions. Risk factors associated with human brucellosis were identified, with unpasteurized dairy consumption and close animal contact being predominant. Various professions such as farmers, dairy factory workers, and agriculture workers showed higher prevalence rate. Gender analysis indicated a prevalence rate of 18.02 % (95 % CI: 11.55-25.51 %) in males and 13.61 % (95 % CI: 10.8-16.68 %) in females, with no significant difference in hospitalization rates. The prevalence rate of Brucella spp. was varied across detection methods, with immunocapture agglutination assay (Brucellacapt) showing the highest estimated prevalence rate of (44.04 %, 95 % CI: 27.71-61.04), followed by PCR (39.84 %, 95 % CI: 20.14-61.39) and culture (29.22 %, 95 % CI: 17.89-42.03). Among Brucella species, Brucella melitensis (B. melitensis) and Brucella abortus (B. abortus) were the highest prevalence rate. Although statistically insignificant, the meta-analysis also revealed an upward trend in prevalence rate from 1993 to 2024, (P value = 0.277).
UNASSIGNED: This comprehensive review emphasizes the need for tailored strategies to control brucellosis in the Middle East, highlighting the importance of timely diagnosis, public awareness, and effective treatment protocols. These findings provide valuable insights for policymakers and healthcare professionals working to mitigate the impact of this disease in the region.
UNASSIGNED: This meta-analysis and systematic review focuses on the prevalence rate, risk factors, and diagnostic methods of human brucellosis in Middle Eastern countries, where the disease remains a significant public health issue. The analysis included 92 studies conducted between 1993 and 2024, following specified inclusion and exclusion criteria among symptomatic patients across these countries. The prevalence rate was calculated by dividing positive samples by total samples. The I2 index and Chi-squared test assessed study heterogeneity. Significant heterogeneity occurred when I2 exceeded 50 %.
UNASSIGNED: The highest prevalence rate was observed in Oman, Lebanon, and Kuwait countries, emphasizing a notable burden of Brucella infection in these regions. Risk factors associated with human brucellosis were identified, with unpasteurized dairy consumption and close animal contact being predominant. Various professions such as farmers, dairy factory workers, and agriculture workers showed higher prevalence rate. Gender analysis indicated a prevalence rate of 18.02 % (95 % CI: 11.55-25.51 %) in males and 13.61 % (95 % CI: 10.8-16.68 %) in females, with no significant difference in hospitalization rates. The prevalence rate of Brucella spp. was varied across detection methods, with immunocapture agglutination assay (Brucellacapt) showing the highest estimated prevalence rate of (44.04 %, 95 % CI: 27.71-61.04), followed by PCR (39.84 %, 95 % CI: 20.14-61.39) and culture (29.22 %, 95 % CI: 17.89-42.03). Among Brucella species, Brucella melitensis (B. melitensis) and Brucella abortus (B. abortus) were the highest prevalence rate. Although statistically insignificant, the meta-analysis also revealed an upward trend in prevalence rate from 1993 to 2024, (P value = 0.277).
UNASSIGNED: This comprehensive review emphasizes the need for tailored strategies to control brucellosis in the Middle East, highlighting the importance of timely diagnosis, public awareness, and effective treatment protocols. These findings provide valuable insights for policymakers and healthcare professionals working to mitigate the impact of this disease in the region.
摘要：
■人类布鲁氏菌病，由细菌布鲁氏菌引起的，是全球范围内的重大传染病，也被称为地中海热或马耳他热。
■本荟萃分析和系统评价的重点是患病率，危险因素，以及中东国家人类布鲁氏菌病的诊断方法，这种疾病仍然是一个重大的公共卫生问题。该分析包括1993年至2024年之间进行的92项研究，遵循这些国家有症状患者的特定纳入和排除标准。患病率是通过将阳性样本除以总样本来计算的。I2指数和卡方检验评估了研究的异质性。当I2超过50%时发生显著的异质性。
■在阿曼的患病率最高，黎巴嫩,和科威特国家，强调这些地区布鲁氏菌感染的显著负担。确定了与人类布鲁氏菌病相关的危险因素，主要是未经巴氏消毒的乳制品消费和密切的动物接触。各种职业，如农民，乳品厂工人,农业工人的患病率较高。性别分析表明，男性患病率为18.02％（95％CI：11.55-25.51％），女性患病率为13.61％（95％CI：10.8-16.68％），住院率无显著差异。布鲁氏菌的患病率。不同的检测方法不同，免疫捕获凝集试验(Brucellacapt)显示最高的估计患病率(44.04%，95%CI：27.71-61.04），其次是PCR(39.84%，95%CI：20.14-61.39）和培养（29.22%，95%CI：17.89-42.03）。在布鲁氏菌物种中，布鲁氏菌（B.melitensis）和流产布鲁氏菌（B.流产)是患病率最高的。虽然在统计上微不足道，荟萃分析还显示,从1993年到2024年,患病率呈上升趋势(P值=0.277).
■这份全面审查强调需要制定量身定制的策略来控制中东的布鲁氏菌病，强调及时诊断的重要性，公众意识,和有效的治疗方案。这些发现为政策制定者和医疗保健专业人员提供了有价值的见解，以减轻这种疾病在该地区的影响。
■本荟萃分析和系统评价的重点是患病率，危险因素，以及中东国家人类布鲁氏菌病的诊断方法，这种疾病仍然是一个重大的公共卫生问题。该分析包括1993年至2024年之间进行的92项研究，遵循这些国家有症状患者的特定纳入和排除标准。患病率是通过将阳性样本除以总样本来计算的。I2指数和卡方检验评估了研究的异质性。当I2超过50%时发生显著的异质性。
■在阿曼的患病率最高，黎巴嫩,和科威特国家，强调这些地区布鲁氏菌感染的显著负担。确定了与人类布鲁氏菌病相关的危险因素，主要是未经巴氏消毒的乳制品消费和密切的动物接触。各种职业，如农民，乳品厂工人,农业工人的患病率较高。性别分析表明，男性患病率为18.02％（95％CI：11.55-25.51％），女性患病率为13.61％（95％CI：10.8-16.68％），住院率无显著差异。布鲁氏菌的患病率。不同的检测方法不同，免疫捕获凝集试验(Brucellacapt)显示最高的估计患病率(44.04%，95%CI：27.71-61.04），其次是PCR(39.84%，95%CI：20.14-61.39）和培养（29.22%，95%CI：17.89-42.03）。在布鲁氏菌物种中，布鲁氏菌（B.melitensis）和流产布鲁氏菌（B.流产)是患病率最高的。虽然在统计上微不足道，荟萃分析还显示,从1993年到2024年,患病率呈上升趋势(P值=0.277).
■这份全面审查强调需要制定量身定制的策略来控制中东的布鲁氏菌病，强调及时诊断的重要性，公众意识,和有效的治疗方案。这些发现为政策制定者和医疗保健专业人员提供了有价值的见解，以减轻这种疾病在该地区的影响。
