PDF(Pubmed)
Abstract：
UNASSIGNED: The impact of recurrent angioedema can be severely debilitating and remains difficult to quantify. Several standardized patient-reported outcome measures (PROMs), including the Angioedema Activity Score (AAS), Angioedema Quality of Life (AE-QoL) questionnaire, and Angioedema Control Test (AECT), have been developed and translated into different languages. However, these PROMs have yet to be validated in Chinese individuals, and their correlations in the Chinese population remain unknown.
UNASSIGNED: Our aim was to validate the Chinese versions of the AAS, AE-QoL questionnaire, and AECT and assess their intercorrelations.
UNASSIGNED: A prospective cohort of 118 Chinese patients with recurrent angioedema at the Angioedema and Urticaria Centre of Reference and Excellence in Hong Kong completed the traditional Chinese versions of the AAS, AE-QoL questionnaire, and AECT. We analyzed the reliability and validity of these PROMs and their correlations with each other as well as with generic PROMs.
UNASSIGNED: The Chinese AAS, AE-QoL questionnaire, and AECT demonstrated excellent internal consistency (Cronbach α = 0.920, 0.976, and 0.832, respectively; McDonald ω = 0.972, 0.977, and 0.901, respectively). Confirmatory factor analysis for the AE-QoL questionnaire showed an acceptable fit with the 4-dimensional model (comparative fit index = 0.869; Tucker-Lewis index = 0.842). The AECT showed significant correlations with both the AAS and AE-QoL questionnaire (ρ = -0.750 and -0.456 respectively [both P < .05]). The AE-QoL questionnaire was moderately correlated with certain domains of generic PROMs such as the Work Productivity and Activity Impairment Questionnaire: General Health, version 2.0, and the Short Form 12-Item Health Survey, version 2 (all ρ < 0.60).
UNASSIGNED: The Chinese AE-QoL questionnaire, AAS, and AECT are valid and reliable tools for use with Chinese patients. More validated tools should be made available to improve patient care and research for all patients with angioedema globally.
UNASSIGNED: Our aim was to validate the Chinese versions of the AAS, AE-QoL questionnaire, and AECT and assess their intercorrelations.
UNASSIGNED: A prospective cohort of 118 Chinese patients with recurrent angioedema at the Angioedema and Urticaria Centre of Reference and Excellence in Hong Kong completed the traditional Chinese versions of the AAS, AE-QoL questionnaire, and AECT. We analyzed the reliability and validity of these PROMs and their correlations with each other as well as with generic PROMs.
UNASSIGNED: The Chinese AAS, AE-QoL questionnaire, and AECT demonstrated excellent internal consistency (Cronbach α = 0.920, 0.976, and 0.832, respectively; McDonald ω = 0.972, 0.977, and 0.901, respectively). Confirmatory factor analysis for the AE-QoL questionnaire showed an acceptable fit with the 4-dimensional model (comparative fit index = 0.869; Tucker-Lewis index = 0.842). The AECT showed significant correlations with both the AAS and AE-QoL questionnaire (ρ = -0.750 and -0.456 respectively [both P < .05]). The AE-QoL questionnaire was moderately correlated with certain domains of generic PROMs such as the Work Productivity and Activity Impairment Questionnaire: General Health, version 2.0, and the Short Form 12-Item Health Survey, version 2 (all ρ < 0.60).
UNASSIGNED: The Chinese AE-QoL questionnaire, AAS, and AECT are valid and reliable tools for use with Chinese patients. More validated tools should be made available to improve patient care and research for all patients with angioedema globally.
摘要：
■复发性血管性水肿的影响可能会严重衰弱，并且仍然难以量化。几种标准化的患者报告结果测量(PROM)，包括血管水肿活动评分（AAS），血管性水肿生活质量（AE-QoL）问卷，和血管性水肿控制测试（AECT），已经被开发并翻译成不同的语言。然而,这些PROM尚未在中国个人中得到验证，它们在中国人口中的相关性仍然未知。
■我们的目的是验证AAS的中文版本，AE-QoL问卷，和AECT，并评估它们的相互关系。
■在香港血管水肿和荨麻疹参考和卓越中心进行的118例复发性血管性水肿的中国患者的前瞻性队列研究完成了AAS的繁体中文版本，AE-QoL问卷，和AECT。我们分析了这些PROM的信度和效度及其相互之间以及与通用PROM的相关性。
■中国AAS，AE-QoL问卷，和AECT表现出优异的内部一致性（Cronbachα分别为0.920、0.976和0.832；McDonaldω分别为0.972、0.977和0.901）。AE-QoL问卷的验证性因素分析显示与4维模型的拟合可接受(比较拟合指数=0.869;Tucker-Lewis指数=0.842)。AECT与AAS和AE-QoL问卷均具有显着相关性（ρ分别为-0.750和-0.456[均P<0.05]）。AE-QoL问卷与通用PROM的某些领域中度相关，例如工作生产力和活动损害问卷：一般健康，2.0版和简短表格12项健康调查，版本2(所有ρ<0.60)。
■中国AE-QoL问卷，AAS,和AECT是中国患者使用的有效和可靠的工具。应提供更多经过验证的工具，以改善全球所有血管性水肿患者的患者护理和研究。
■我们的目的是验证AAS的中文版本，AE-QoL问卷，和AECT，并评估它们的相互关系。
■在香港血管水肿和荨麻疹参考和卓越中心进行的118例复发性血管性水肿的中国患者的前瞻性队列研究完成了AAS的繁体中文版本，AE-QoL问卷，和AECT。我们分析了这些PROM的信度和效度及其相互之间以及与通用PROM的相关性。
■中国AAS，AE-QoL问卷，和AECT表现出优异的内部一致性（Cronbachα分别为0.920、0.976和0.832；McDonaldω分别为0.972、0.977和0.901）。AE-QoL问卷的验证性因素分析显示与4维模型的拟合可接受(比较拟合指数=0.869;Tucker-Lewis指数=0.842)。AECT与AAS和AE-QoL问卷均具有显着相关性（ρ分别为-0.750和-0.456[均P<0.05]）。AE-QoL问卷与通用PROM的某些领域中度相关，例如工作生产力和活动损害问卷：一般健康，2.0版和简短表格12项健康调查，版本2(所有ρ<0.60)。
■中国AE-QoL问卷，AAS,和AECT是中国患者使用的有效和可靠的工具。应提供更多经过验证的工具，以改善全球所有血管性水肿患者的患者护理和研究。
