Abstract：
OBJECTIVE: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs).
METHODS: Population-Based Study.
METHODS: Data sourced from the Global Burden of Disease Study 2019.
METHODS: Individuals diagnosed with FeBGCs.
METHODS: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.
METHODS: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.
RESULTS: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30-510.51), cervical cancer: 210.64 (95% UI: 177.67-234.85), ovarian cancer: 124.68 (95% UI: 109.13-138.67) and uterine cancer: 210.64 (95% UI: 177.67-234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: -0.51 (95% CI: -0.57 to -0.45); Cervical cancer: -0.95 (95% CI: -0.99 to -0.89); Ovarian cancer: -0.08 (95% CI: -0.12 to -0.04); and Uterine cancer: -0.84 (95% CI: -0.93 to -0.75). In the Social Inequalities Analysis (1990-2019) the SII changed from 689.26 to 607.08 for Breast, from -226.66 to -239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.
CONCLUSIONS: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.
METHODS: Population-Based Study.
METHODS: Data sourced from the Global Burden of Disease Study 2019.
METHODS: Individuals diagnosed with FeBGCs.
METHODS: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.
METHODS: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.
RESULTS: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30-510.51), cervical cancer: 210.64 (95% UI: 177.67-234.85), ovarian cancer: 124.68 (95% UI: 109.13-138.67) and uterine cancer: 210.64 (95% UI: 177.67-234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: -0.51 (95% CI: -0.57 to -0.45); Cervical cancer: -0.95 (95% CI: -0.99 to -0.89); Ovarian cancer: -0.08 (95% CI: -0.12 to -0.04); and Uterine cancer: -0.84 (95% CI: -0.93 to -0.75). In the Social Inequalities Analysis (1990-2019) the SII changed from 689.26 to 607.08 for Breast, from -226.66 to -239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.
CONCLUSIONS: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.
摘要：
目的：分析全球负担，女性乳腺癌和妇科癌症（FeBGC）的趋势和跨国不平等。
方法：基于人群的研究。
方法：数据来自2019年全球疾病负担研究。
方法：诊断为FeBGC的个体。
方法：年龄标准化死亡率（ASMR），年龄标准化残疾调整寿命年(DALYs)率(ASDRs)及其95%不确定区间(UI)描述了这一负担。年龄标准化率（ASR）的估计年度百分比变化（EAPC）及其置信区间（CI）说明了趋势。使用不平等斜率指数（SII）和集中指数对社会不平等进行了量化。
方法：主要结果指标是FeBGC的负担及其不平等随时间的趋势。
结果：2019年，每10万名女性的ASDR如下：乳腺癌：473.83（95％UI：437.30-510.51），宫颈癌：210.64（95％UI：177.67-234.85），卵巢癌：124.68（95％UI：109.13-138.67）和子宫癌：210.64（95％UI：177.67-234.85）。从1990年到2019年的每年趋势表示为ASDR的EAPC，其中：乳腺癌：-0.51（95％CI：-0.57至-0.45）;宫颈癌：-0.95（95％CI：-0.99至-0.89）;卵巢癌：-0.08（95％CI：-0.12至-0.04）;和子宫癌：-0.84（95％CI：-0.93至-0.75）。在社会不平等分析(1990-2019年)中，乳腺的SII从689.26更改为607.08，从-226.66到-239.92宫颈，卵巢癌从222.45到228.83，子宫癌从74.61到103.58。浓度指数值范围为0.2至0.4。
结论：从1990年到2019年，全球FeBGC的负担呈下降趋势。社会人口指数（SDI）较高的国家或地区承担较高的DALYs乳房负担，卵巢癌和子宫癌，而SDI较低的人承受着较重的子宫颈癌负担。这些不平等随着时间的推移而增加。
方法：基于人群的研究。
方法：数据来自2019年全球疾病负担研究。
方法：诊断为FeBGC的个体。
方法：年龄标准化死亡率（ASMR），年龄标准化残疾调整寿命年(DALYs)率(ASDRs)及其95%不确定区间(UI)描述了这一负担。年龄标准化率（ASR）的估计年度百分比变化（EAPC）及其置信区间（CI）说明了趋势。使用不平等斜率指数（SII）和集中指数对社会不平等进行了量化。
方法：主要结果指标是FeBGC的负担及其不平等随时间的趋势。
结果：2019年，每10万名女性的ASDR如下：乳腺癌：473.83（95％UI：437.30-510.51），宫颈癌：210.64（95％UI：177.67-234.85），卵巢癌：124.68（95％UI：109.13-138.67）和子宫癌：210.64（95％UI：177.67-234.85）。从1990年到2019年的每年趋势表示为ASDR的EAPC，其中：乳腺癌：-0.51（95％CI：-0.57至-0.45）;宫颈癌：-0.95（95％CI：-0.99至-0.89）;卵巢癌：-0.08（95％CI：-0.12至-0.04）;和子宫癌：-0.84（95％CI：-0.93至-0.75）。在社会不平等分析(1990-2019年)中，乳腺的SII从689.26更改为607.08，从-226.66到-239.92宫颈，卵巢癌从222.45到228.83，子宫癌从74.61到103.58。浓度指数值范围为0.2至0.4。
结论：从1990年到2019年，全球FeBGC的负担呈下降趋势。社会人口指数（SDI）较高的国家或地区承担较高的DALYs乳房负担，卵巢癌和子宫癌，而SDI较低的人承受着较重的子宫颈癌负担。这些不平等随着时间的推移而增加。
