{Reference Type}: Journal Article
{Title}: The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study.
{Author}: Cheng L;Wang Z;Li R;Qiang M;Yang C;Yang G;Xie Y;Yuan R;Xu Y;
{Journal}: BJOG
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 5
{Factor}: 7.331
{DOI}: 10.1111/1471-0528.17925
{Abstract}: <B>OBJECTIVE: </B>To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs).<BR><B>METHODS: </B>Population-Based Study.<BR><B>METHODS: </B>Data sourced from the Global Burden of Disease Study 2019.<BR><B>METHODS: </B>Individuals diagnosed with FeBGCs.<BR><B>METHODS: </B>Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.<BR><B>METHODS: </B>The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.<BR><B>RESULTS: </B>In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30-510.51), cervical cancer: 210.64 (95% UI: 177.67-234.85), ovarian cancer: 124.68 (95% UI: 109.13-138.67) and uterine cancer: 210.64 (95% UI: 177.67-234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: -0.51 (95% CI: -0.57 to -0.45); Cervical cancer: -0.95 (95% CI: -0.99 to -0.89); Ovarian cancer: -0.08 (95% CI: -0.12 to -0.04); and Uterine cancer: -0.84 (95% CI: -0.93 to -0.75). In the Social Inequalities Analysis (1990-2019) the SII changed from 689.26 to 607.08 for Breast, from -226.66 to -239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.<BR><B>CONCLUSIONS: </B>The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.