Abstract：
Strongyloides stercoralis in humans often presents as a chronic asymptomatic infection. Diagnosis can be challenging due to the limited sensitivity of faecal-based parasitological techniques. A prototype lateral flow rapid diagnostic test (RDT) for the detection of specific antibodies against Strongyloides stercoralis (SsRapid) was evaluated using 143 samples from the serum bank of the Swiss Tropical and Public Health Institute. Group 1 (n = 30) comprised serum samples from larvae-positive individuals; the RDT\'s diagnostic sensitivity was 97 % (29/30). Group II comprised serum samples from patients with other parasitic infections (n = 86) and Swiss blood donors (n = 27); the RDT\'s diagnostic specificity for this group was 90 % (102/113). The RDT showed good diagnostic performance and is a promising point-of-care test for detecting human Strongyloides stercoralis infection.
摘要：
人类中的类圆线虫通常表现为慢性无症状感染。由于基于粪便的寄生虫学技术的灵敏度有限，诊断可能具有挑战性。使用来自瑞士热带和公共卫生研究所血清库的143份样品，评估了用于检测针对赤圆线虫（SsRapid）的特异性抗体的原型侧流快速诊断测试（RDT）。第1组（n=30）包括幼虫阳性个体的血清样本；RDT的诊断灵敏度为97％（29/30）。II组包括来自其他寄生虫感染患者（n=86）和瑞士献血者（n=27）的血清样本；RDT对该组的诊断特异性为90％（102/113）。RDT显示出良好的诊断性能，是一种有前途的即时检测方法，可用于检测人类圆圆线虫感染。
