PDF(Pubmed)
Abstract：
The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array of biological, social, and environmental factors can have lasting impacts on brain structure and function. To understand how prenatal and early life experiences alter neurodevelopmental trajectories and shape health outcomes, several NIH Institutes, Centers, and Offices collaborated to support and launch the HEALthy Brain and Child Development (HBCD) Study. The HBCD Study is a multi-site prospective longitudinal cohort study, that will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Influenced by the success of the ongoing Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) and in partnership with the NIH Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, the HBCD Study aims to establish a diverse cohort of over 7000 pregnant participants to understand how early life experiences, including prenatal exposure to addictive substances and adverse social environments as well as their interactions with an individual\'s genes, can affect neurodevelopmental trajectories and outcomes. Knowledge gained from the HBCD Study will help identify targets for early interventions and inform policies that promote resilience and mitigate the neurodevelopmental effects of adverse childhood experiences and environments.
摘要：
人类大脑在生命的最初几年经历了快速发育。从子宫开始，各种各样的生物，社会,环境因素会对大脑结构和功能产生持久影响。为了了解产前和早期生活经历如何改变神经发育轨迹和塑造健康结果，几个NIH研究所,中心,和办公室合作支持和启动健康大脑和儿童发育（HBCD）研究。六溴环十二烷研究是一项多地点前瞻性纵向队列研究，它将检查人类的大脑，认知，行为，社会,和情感发展开始于出生前和计划到幼儿时期。受正在进行的青少年大脑认知发展SM研究（ABCD研究®）的成功影响，并与NIH合作帮助终止成瘾长期®倡议，或NIHHEALInitiative®，六溴环十二烷研究旨在建立一个由7000多名怀孕参与者组成的多样化队列，以了解早期生活经历，包括产前暴露于成瘾物质和不利的社会环境，以及它们与个体基因的相互作用，会影响神经发育轨迹和结果。从六溴环十二烷研究中获得的知识将有助于确定早期干预的目标，并为促进韧性和减轻不良儿童经历和环境对神经发育影响的政策提供信息。
