Abstract：
The compound Honokiol, derived from the bark of Magnolia officinalis, possesses the ability to induce apoptosis and inhibit cellular damage caused by reactive oxygen species. The objective of this study was to investigate the toxicological and histopathological effects of Honokiol on zebrafish (Danio rerio) through conducting a semistatic acute toxicity test involving immersion in an Honokiol-containing solution. The results showed that the toxic effects of Honokiol on zebrafish were primarily manifested in the liver and gills. When exposed to 0.6 mg/L of Honokiol, it could lead to liver hemorrhage as well as swelling and necrosis of gill tissues, and high concentrations of Honokiol could trigger inflammatory responses. Additionally, research found that Honokiol could induce apoptosis in liver and gill tissues through the P53 pathway and possessed the ability to enhance antioxidation. The present findings significantly contribute to a more profound understanding of the toxic impact of Honokiol and its underlying mechanism, thereby providing a valuable reference for the future safe utilization of Honokiol and related pharmaceutical advancements.
摘要：
化合物和厚朴酚,来源于厚朴的树皮，具有诱导细胞凋亡和抑制活性氧引起的细胞损伤的能力。这项研究的目的是通过进行半静态急性毒性试验，研究和厚朴酚对斑马鱼（Daniorerio）的毒理学和组织病理学影响，该试验涉及浸入含和厚朴酚的溶液中。结果表明，和厚朴酚对斑马鱼的毒性作用主要表现在肝脏和ill。当暴露于0.6毫克/升的和厚朴酚时，它可能导致肝脏出血以及ill组织肿胀和坏死，高浓度和厚朴酚可引发炎症反应。此外,研究发现,和厚朴酚可通过P53途径诱导肝脏和ill组织凋亡,并具有增强抗氧化能力。本研究的发现大大有助于更深刻地理解和厚朴酚的毒性影响及其潜在的机制，从而为今后和厚朴酚的安全利用及相关药物进展提供有价值的参考。
