PDF(Pubmed)
Abstract：
BACKGROUND: Disseminated non-tuberculous mycobacteria (dNTM) infections are mostly reported among individuals with an underlying congenital or acquired immunodeficiency or receiving immunosuppressive treatment, but are rarely documented in otherwise healthy subjects.
METHODS: We describe a case of recurrent disseminated mycobacterial infection in an apparently immunocompetent Chinese woman. Mycobacterium szulgai and Mycobacterium avium-complex were identified in distinct episodes. Long-term antimycobacterial therapy was administered given the occurrence of recurrent events when off-treatment. Successful management over more than 10 years and immunologic data are reported.
CONCLUSIONS: This case-report highlights that dNTM should be suspected also among apparently immunocompetent hosts and that thorough assessment of underling immune-impairments is helpful to define patients\' management. Long-term antimycobacterial therapy and close monitoring is required to grant successful outcomes in case of recurrent dNTM infections.
METHODS: We describe a case of recurrent disseminated mycobacterial infection in an apparently immunocompetent Chinese woman. Mycobacterium szulgai and Mycobacterium avium-complex were identified in distinct episodes. Long-term antimycobacterial therapy was administered given the occurrence of recurrent events when off-treatment. Successful management over more than 10 years and immunologic data are reported.
CONCLUSIONS: This case-report highlights that dNTM should be suspected also among apparently immunocompetent hosts and that thorough assessment of underling immune-impairments is helpful to define patients\' management. Long-term antimycobacterial therapy and close monitoring is required to grant successful outcomes in case of recurrent dNTM infections.
摘要：
背景：播散性非结核分枝杆菌（dNTM）感染主要在患有先天性或获得性免疫缺陷或接受免疫抑制治疗的个体中报道，但很少记录在其他健康的受试者中。
方法：我们描述了一例表现为免疫功能正常的中国女性反复播散的分枝杆菌感染病例。在不同的事件中鉴定了szulgai分枝杆菌和鸟分枝杆菌复合物。考虑到停药时复发事件的发生，给予长期抗分枝杆菌治疗。超过10年的成功管理和免疫学数据报告。
结论：本病例报告强调，在免疫功能明显的宿主中也应怀疑dNTM，并且对潜在免疫损伤的彻底评估有助于确定患者的管理。在复发性dNTM感染的情况下，需要长期的抗分枝杆菌治疗和密切监测才能获得成功的结果。
方法：我们描述了一例表现为免疫功能正常的中国女性反复播散的分枝杆菌感染病例。在不同的事件中鉴定了szulgai分枝杆菌和鸟分枝杆菌复合物。考虑到停药时复发事件的发生，给予长期抗分枝杆菌治疗。超过10年的成功管理和免疫学数据报告。
结论：本病例报告强调，在免疫功能明显的宿主中也应怀疑dNTM，并且对潜在免疫损伤的彻底评估有助于确定患者的管理。在复发性dNTM感染的情况下，需要长期的抗分枝杆菌治疗和密切监测才能获得成功的结果。
