PDF(Pubmed)
Abstract：
OBJECTIVE: While significant evidence supports the benefits of normothermic cardiopulmonary bypass (NCPB) over hypothermic techniques, many institutions in developing countries, including ours, continue to employ hypothermic methods. This study aimed to assess the early postoperative outcomes of normothermic cardiopulmonary bypass (NCPB) for complete surgical repair via the Tetralogy of Fallot (TOF) within our national context.
METHODS: We conducted this study in the Pediatric Cardiac Intensive Care Unit (PCICU) at the University Children\'s Hospital. One hundred patients who underwent complete TOF repair were enrolled and categorized into two groups: the normothermic group (n = 50, temperature 35-37 °C) and the moderate hypothermic group (n = 50, temperature 28-32 °C). We evaluated mortality, morbidity, and postoperative complications in the PCICU as outcome measures.
RESULTS: The demographic characteristics were similar between the two groups. However, the cardiopulmonary bypass (CPB) time and aortic cross-clamp (ACC) time were notably longer in the hypothermic group. The study recorded seven deaths, yielding an overall mortality rate of 7%. No significant differences were observed between the two groups concerning mortality, morbidity, or postoperative complications in the PCICU.
CONCLUSIONS: Our findings suggest that normothermic procedures, while not demonstrably effective, are safe for pediatric cardiac surgery. Further research is warranted to substantiate and endorse the adoption of this technique.
METHODS: We conducted this study in the Pediatric Cardiac Intensive Care Unit (PCICU) at the University Children\'s Hospital. One hundred patients who underwent complete TOF repair were enrolled and categorized into two groups: the normothermic group (n = 50, temperature 35-37 °C) and the moderate hypothermic group (n = 50, temperature 28-32 °C). We evaluated mortality, morbidity, and postoperative complications in the PCICU as outcome measures.
RESULTS: The demographic characteristics were similar between the two groups. However, the cardiopulmonary bypass (CPB) time and aortic cross-clamp (ACC) time were notably longer in the hypothermic group. The study recorded seven deaths, yielding an overall mortality rate of 7%. No significant differences were observed between the two groups concerning mortality, morbidity, or postoperative complications in the PCICU.
CONCLUSIONS: Our findings suggest that normothermic procedures, while not demonstrably effective, are safe for pediatric cardiac surgery. Further research is warranted to substantiate and endorse the adoption of this technique.
摘要：
目的：虽然有大量证据支持常温体外循环（NCPB）优于低温技术，发展中国家的许多机构，包括我们的,继续使用低温方法。本研究旨在评估常温体外循环（NCPB）在我们国家范围内通过法洛四联症（TOF）进行完整手术修复的早期术后结果。
方法：我们在大学儿童医院的儿科心脏重症监护病房（PCICU）进行了这项研究。100例接受完全TOF修复的患者被纳入并分为两组：常温组（n=50，温度35-37°C）和中度低温组（n=50，温度28-32°C）。我们评估了死亡率，发病率，并将PCICU的术后并发症作为结局指标。
结果：两组人口统计学特征相似。然而,低温组的体外循环(CPB)时间和主动脉阻断(ACC)时间明显更长.研究记录了7人死亡,总体死亡率为7%。两组在死亡率方面没有观察到显著差异。发病率，或PCICU的术后并发症。
结论：我们的研究结果表明，常温手术，虽然没有明显的效果，对于小儿心脏手术是安全的。需要进一步的研究来证实和认可这种技术的采用。
方法：我们在大学儿童医院的儿科心脏重症监护病房（PCICU）进行了这项研究。100例接受完全TOF修复的患者被纳入并分为两组：常温组（n=50，温度35-37°C）和中度低温组（n=50，温度28-32°C）。我们评估了死亡率，发病率，并将PCICU的术后并发症作为结局指标。
结果：两组人口统计学特征相似。然而,低温组的体外循环(CPB)时间和主动脉阻断(ACC)时间明显更长.研究记录了7人死亡,总体死亡率为7%。两组在死亡率方面没有观察到显著差异。发病率，或PCICU的术后并发症。
结论：我们的研究结果表明，常温手术，虽然没有明显的效果，对于小儿心脏手术是安全的。需要进一步的研究来证实和认可这种技术的采用。
