恩扎鲁胺抑制 PEX10 功能并使前列腺癌细胞对 ROS 激活剂敏感。
Mesh : Humans Phenylthiohydantoin / pharmacology analogs & derivatives Male Benzamides / pharmacology Nitriles / pharmacology Reactive Oxygen Species / metabolism Prostatic Neoplasms / drug therapy metabolism pathology Cell Line, Tumor Receptors, Androgen / metabolism Hepatocyte Nuclear Factor 3-alpha / metabolism Animals Mice Membrane Proteins / metabolism Gene Expression Regulation, Neoplastic / drug effects Mice, Nude
来 源:
DOI:10.1038/s41419-024-06937-7
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