METHODS: This is a prospective cohort study.
METHODS: This study leveraged data from a sub-cohort of the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project. Participants aged 35-75 years without a prevalent stroke and MI were enrolled from January 2016 to December 2020, with follow-up through December 2021. Five common comorbidities were collected at baseline, and the study outcome was hospitalization for stroke and MI identified from the Inpatients Registry.
RESULTS: Of 100,873 participants, the mean age was 54.2 (±10.2) years, 34.2% were ≥60 years old, and 60.8% were women. After a median follow-up of 3.52 years, 4156 participants had stroke/MI. The strengths of the associations between hypertension, diabetes, and obesity with stroke/MI were higher in younger individuals than in seniors, and obesity had a more hazardous impact on stroke/MI in men than in women. The five comorbidities collectively explained a higher population attributable fraction (PAF) for stroke/MI in the young group (51.5[46.9, 55.7] %) than in the senior group (41.3[37.0, 45.4] %), in men (45.6[40.9, 49.9] %) than in women (41.1[36.1, 45.7] %).
CONCLUSIONS: Most of the common comorbidities were significantly associated with stroke and MI. Several age and sex differences in the impacts of comorbidities on stroke/MI were observed, highlighting the importance of age- and sex-specific preventive strategies to reduce premature stroke and MI.
方法:这是一项前瞻性队列研究。
方法:本研究利用了中国以患者为中心的百万人心脏事件评估(PEACE)项目子队列的数据。从2016年1月至2020年12月,年龄在35-75岁之间,没有普遍中风和MI的参与者被纳入,随访至2021年12月。基线时收集了五种常见的合并症,研究结果为住院患者登记处确定的卒中和MI住院。
结果:在100,873名参与者中,平均年龄为54.2(±10.2)岁,≥60岁的占34.2%,60.8%是女性。经过3.52年的中位随访,4156名参与者有中风/MI。高血压,糖尿病,与老年人相比,年轻人的卒中/MI肥胖更高,肥胖对男性卒中/MI的影响比女性更危险.五种合并症共同解释了年轻组(51.5[46.9,55.7]%)比老年组(41.3[37.0,45.4]%)更高的卒中/MI人群归因分数(PAF)。男性(45.6[40.9,49.9]%)高于女性(41.1[36.1,45.7]%)。
结论:大多数常见合并症与卒中和MI显著相关。观察到合并症对卒中/MI的影响的一些年龄和性别差异。强调年龄和性别特异性预防策略对减少早发卒中和MI的重要性。