Abstract：
OBJECTIVE: This study aims to evaluate the age- and sex-specific associations of comorbidities with stroke and MI and further calculate the population-attributable fractions (PAFs) of five comorbid diseases for stroke and myocardial infarction (MI) by age and sex.
METHODS: This is a prospective cohort study.
METHODS: This study leveraged data from a sub-cohort of the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project. Participants aged 35-75 years without a prevalent stroke and MI were enrolled from January 2016 to December 2020, with follow-up through December 2021. Five common comorbidities were collected at baseline, and the study outcome was hospitalization for stroke and MI identified from the Inpatients Registry.
RESULTS: Of 100,873 participants, the mean age was 54.2 (±10.2) years, 34.2% were ≥60 years old, and 60.8% were women. After a median follow-up of 3.52 years, 4156 participants had stroke/MI. The strengths of the associations between hypertension, diabetes, and obesity with stroke/MI were higher in younger individuals than in seniors, and obesity had a more hazardous impact on stroke/MI in men than in women. The five comorbidities collectively explained a higher population attributable fraction (PAF) for stroke/MI in the young group (51.5[46.9, 55.7] %) than in the senior group (41.3[37.0, 45.4] %), in men (45.6[40.9, 49.9] %) than in women (41.1[36.1, 45.7] %).
CONCLUSIONS: Most of the common comorbidities were significantly associated with stroke and MI. Several age and sex differences in the impacts of comorbidities on stroke/MI were observed, highlighting the importance of age- and sex-specific preventive strategies to reduce premature stroke and MI.
METHODS: This is a prospective cohort study.
METHODS: This study leveraged data from a sub-cohort of the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project. Participants aged 35-75 years without a prevalent stroke and MI were enrolled from January 2016 to December 2020, with follow-up through December 2021. Five common comorbidities were collected at baseline, and the study outcome was hospitalization for stroke and MI identified from the Inpatients Registry.
RESULTS: Of 100,873 participants, the mean age was 54.2 (±10.2) years, 34.2% were ≥60 years old, and 60.8% were women. After a median follow-up of 3.52 years, 4156 participants had stroke/MI. The strengths of the associations between hypertension, diabetes, and obesity with stroke/MI were higher in younger individuals than in seniors, and obesity had a more hazardous impact on stroke/MI in men than in women. The five comorbidities collectively explained a higher population attributable fraction (PAF) for stroke/MI in the young group (51.5[46.9, 55.7] %) than in the senior group (41.3[37.0, 45.4] %), in men (45.6[40.9, 49.9] %) than in women (41.1[36.1, 45.7] %).
CONCLUSIONS: Most of the common comorbidities were significantly associated with stroke and MI. Several age and sex differences in the impacts of comorbidities on stroke/MI were observed, highlighting the importance of age- and sex-specific preventive strategies to reduce premature stroke and MI.
摘要：
目的：本研究旨在评估中风和心肌梗死合并症的年龄和性别特异性关联，并进一步计算中风和心肌梗死（MI）的五种合并症的人群归因分数（PAFs）年龄和性别。
方法：这是一项前瞻性队列研究。
方法：本研究利用了中国以患者为中心的百万人心脏事件评估（PEACE）项目子队列的数据。从2016年1月至2020年12月，年龄在35-75岁之间，没有普遍中风和MI的参与者被纳入，随访至2021年12月。基线时收集了五种常见的合并症，研究结果为住院患者登记处确定的卒中和MI住院。
结果：在100,873名参与者中，平均年龄为54.2（±10.2）岁，≥60岁的占34.2%，60.8%是女性。经过3.52年的中位随访，4156名参与者有中风/MI。高血压，糖尿病,与老年人相比，年轻人的卒中/MI肥胖更高，肥胖对男性卒中/MI的影响比女性更危险.五种合并症共同解释了年轻组（51.5[46.9,55.7]％）比老年组（41.3[37.0,45.4]％）更高的卒中/MI人群归因分数（PAF）。男性（45.6[40.9，49.9]％）高于女性（41.1[36.1，45.7]％）。
结论：大多数常见合并症与卒中和MI显著相关。观察到合并症对卒中/MI的影响的一些年龄和性别差异。强调年龄和性别特异性预防策略对减少早发卒中和MI的重要性。
方法：这是一项前瞻性队列研究。
方法：本研究利用了中国以患者为中心的百万人心脏事件评估（PEACE）项目子队列的数据。从2016年1月至2020年12月，年龄在35-75岁之间，没有普遍中风和MI的参与者被纳入，随访至2021年12月。基线时收集了五种常见的合并症，研究结果为住院患者登记处确定的卒中和MI住院。
结果：在100,873名参与者中，平均年龄为54.2（±10.2）岁，≥60岁的占34.2%，60.8%是女性。经过3.52年的中位随访，4156名参与者有中风/MI。高血压，糖尿病,与老年人相比，年轻人的卒中/MI肥胖更高，肥胖对男性卒中/MI的影响比女性更危险.五种合并症共同解释了年轻组（51.5[46.9,55.7]％）比老年组（41.3[37.0,45.4]％）更高的卒中/MI人群归因分数（PAF）。男性（45.6[40.9，49.9]％）高于女性（41.1[36.1，45.7]％）。
结论：大多数常见合并症与卒中和MI显著相关。观察到合并症对卒中/MI的影响的一些年龄和性别差异。强调年龄和性别特异性预防策略对减少早发卒中和MI的重要性。
